Effect of Ginsenoside Rg1 on transformation growth factor-beta and brain-derived neurotrophic factor expression in spinal cord injury rats

doi:10.3969/j.issn.2095-4344.2015.18.013

Abstract

Abstract:

BACKGROUND: Transformation growth factor-β (TGF-β) and brain-derived neurotrophic factor (BDNF) are the main regulatory factors in the process of spinal cord injury. There are many researches for TGF-β and BDNF pathogenesis in the spinal cord injury, but the regulation of Ginsenoside Rg1 intervention on TGF-β and BDNF in the spinal cord injury is rarely reported.
OBJECTIVE: To observe the effect of Ginsenoside Rg1 intervention on TGF-β and BDNF expression at the molecular protein levels, and to study the protection effect of Ginsenoside Rg1 on the spinal cord and nerve function after spinal cord injury.
METHODS: Experimental rats were randomly divided into blank control group, model group and Ginsenoside Rg1 group. In the model and Ginsenoside Rg1 groups, spinal cord injury model was established with the impact method in rats. In the Ginsenoside Rg1 group, rats were intraperitoneally injected with 10 mg/kg Ginsenoside Rg1 24 hours after modeling, once per day, for 14 days. Rats in the blank control and model groups were injected with equal saline.
RESULTS AND CONCLUSION: Compared with the control group, serum malondialdehyde levels increased, the content of superoxide dismutase decreased, TGF-β expression levels in spinal cord tissue increased, and BDNF expression levels decreased in the model and Ginsenoside Rg1 groups. Compared with the model group, serum malondialdehyde levels decreased, the content of superoxide dismutase increased, TGF-β expression levels in spinal cord tissue decreased, and BDNF expression levels increased in the Ginsenoside Rg1 group. Ginsenoside Rg1 can protect the injury spinal cord in rats after spinal cord injury.

中国组织工程研究杂志出版内容重点：肾移植；肝移植；移植；心脏移植；组织移植；皮肤移植；皮瓣移植；血管移植；器官移植；组织工程

全文链接：

Key words: Ginsenosides, Spinal Cord Injury, Oxidoreductases, Neurturin

CLC Number:

R318

Sun Jian-zhong, Liu Xin-wei, Guan Hua-peng, Zhang Peng, Liu Qi, Yang Jun, Guo Qun-feng, Ni Bin. Effect of Ginsenoside Rg1 on transformation growth factor-beta and brain-derived neurotrophic factor expression in spinal cord injury rats[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(18): 2862-2866.

Figures/Tables 3

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