Sanqi sodium hyaluronate gel inhibits alpha-smooth muscle actin expression in the epidural scar

doi:10.3969/j.issn.2095-4344.2015.16.011

Abstract

Abstract:

BACKGROUND: Epidural scar after laminectomy is one important reason for the secondary spinal stenosis, and local application of Sanqi sodium hyaluronate gel can prevent epidural scar adhesion after laminectomy.
OBJECTIVE: To study the effects of Sanqi sodium hyaluronate gel on α-smooth muscle actin expression in the process of rabbit’s epidural scar formation.
METHODS: In this study, there were ninety-six rabbits which were randomized into four groups and given 0.5 mL normal saline, 0.5 mL Sanqi concentrated solution, 0.5 mL sodium hyaluronate and 0.5 mL Sanqi sodium hyaluronate gel around the dura. At 1, 2, 4, 8 weeks after treatment, immunohistochemistry staining was employed for analysis of α-smooth muscle actin expression.
RESULTS AND CONCLUSION: At the end of weeks 1 and 2, the expression of α-smooth muscle actin antibody in the normal saline group was significantly higher than that in the other three groups (P < 0.01 or P < 0.05), but there were no significant differences among the Sanqi, sodium hyaluronate and Sanqi sodium hyaluronate gel groups (P > 0.05). At weeks 4 and 8, the expression of α-smooth muscle actin antibody in the Sanqi sodium hyaluronate gel group was significantly lower than that in the other three groups (P < 0.01 or P < 0.05), and there was no significant difference among the latter three groups (P > 0.05). These findings suggest that Sanqi sodium hyaluronate gel can inhibit the expression of α-smooth muscle actin, and thus ease scar contracture.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

全文链接：

Key words: Cicatrix, Actins, Muscle, Smooth, Hyaluronic Acid, Injections, Epidural

CLC Number:

R318

Xu Quan, Pan Yu, Zhou Wei, Zhang Zhao-jie, Liu Can. Sanqi sodium hyaluronate gel inhibits alpha-smooth muscle actin expression in the epidural scar[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(16): 2518-2522.

Figures/Tables 1

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