Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (6): 1095-1098.doi: 10.3969/j.issn.1673-8225.2012.06.031

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Progress in the source and surface markers of brain tumor stem cells

Qiu Shi1, 2, Tan Xiao-hua1, Huang Hui2   

  1. 1Biological Treatment Center, Beijing Military General Hospital of Chinese PLA, Beijing  100068, China; 2Third Military Medical University of Chinese PLA, Chongqing  400038, China
  • Received:2011-09-04 Revised:2011-12-30 Online:2012-02-05 Published:2012-02-05
  • Contact: author: Huang Hui, Associate professor, Third Military Medical University of Chinese PLA, Chongqing 400038, China huanghui@tmmu.edu.cn
  • About author:Qiu Shi★, Master, Technician, Biological Treatment Center, Beijing Military General Hospital of Chinese PLA, Beijing 100068, China; Third Military Medical University of Chinese PLA, Chongqing 400038, China loive@sohu.com

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Abstract:

BACKGROUND: With the study of brain tumors, researchers have found that brain tumor stem cells (BTSCs) play an important role in tumor growth, development, recurrence and metastasis.
OBJECTIVE: To review the source, biological characters and research progress of BCTCs.
METHODS: The Wanfang database and ELSEVIER database were used to search the related articles about BTCTs published between January 1998 and January 2010 with the key words of “brain tumor stem cells” in Chinese and “brain tumor stem cells, BTCTs” in English. Totally 198 literatures were screened out, and finally 25 important articles were selected to review according to the inclusion criteria.
RESULTS AND CONCLUSION: BTCTs may originate from mutation of neural stem cells, BTCTs have the character of self-renewal, multi-differentiation potency. CD133 and Nestin is the surface biomarker of BTCTs that has been widely used. Study of BTCTs is helpful to clarify the growth mechanism, biological character, clinical treatment and prognosis analysis of the brain tumor.

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