Application of skin-derived precursors in the regenerative medicine

doi:10.3969/j.issn.2095-4344.2012.49.029

Abstract

Abstract:

BACKGROUND: Skin-derived precursors are the new kind of multipotent progenitor cells that derived from the dermis. Recently, great progress has been made in studies and applications about skin-derived precursors.
OBJECTIVE: To summarize the research progress in skin-derived precursors.
METHODS: Articles related to skin-derived precursors were retrieved in CNKI database and PubMed database (1998-01/2011-12). The key words are “skin-derived precursor, hair-follicle, stem cells, neurons, schwann cells, smooth muscle cells, insulin-producing cells, bone repair, regenerative medicine, tissue engineering” in English and “skin-derived precursor, hair-follicle stem cells, regenerative medicine, tissue engineering” in Chinese. A total of 35 articles describing research progress in skin-derived precursors were obtained for the review.
RESULTS AND CONCLUSION: Skin-derived precursors as a kind of adult stem cells have been widely used in nerve damage treatment and neural regeneration, construction of tissue-engineered skin and vascular prosthesis, replacement therapy of pancreatic islet, reconstruction of hematopoietic system and promotion of fracture healing due to their advantages including ease to access, multi-lineage differentiation potential, easy amplification and relatively safe. Skin-derived precursors are a source of seed cells for regenerative medicine and tissue engineering research.

CLC Number:

R394.2

Yang Mei,,Ke Ting-yu, Mao Duo, Kong De-ling, Che Yong-zhe, Xu Mian. Application of skin-derived precursors in the regenerative medicine[J]. Chinese Journal of Tissue Engineering Research, 2012, 16(49): 9283-9288.

Figures/Tables 1

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