BACKGROUND: Polylactic acid (HA) materials do not have the good cell affinity of extracellular matrix materials. Hydrogel cross-linked with HA by chemical methods has a good biocompatibility. 
OBJECTIVE: To observe the changes in cell compatibility of new porous polylactic acid (PLA) scaffolds followed its modification with HA.
METHODS: Highly porous PLA scaffolds were made by salting-out method. EDC and HA were used to modify the scaffolds following mild hydrolysis on the surface of scaffolds by NaOH with low concentration.
RESULTS AND CONCLUSION: The modified PLA scaffolds with HA showed three-dimensional microporous structure underscanning electron microscopy, the pore walls and interfaces were smooth, and connection of smaller pores could be seen between the pores. Infiltration of water droplets in the modified PLA scaffolds was rapid. Water-holding capacity and water absorption capacity of the scaffolds were significantly improved. Cell adhesion and proliferation in modified scaffold were better than those unmodified. Density of cartilage cell growth and matrix secretion were more vigorous in the modified PLA scaffolds with HA. The porous three-dimensional structure of PLA scaffolds did not change after their modification with HA, and their water affinity, water absorption capacity, water capacity and biocompatibility were obviously improved after modification.