Abstract:

BACKGROUND: Delayed graft function (DGF) is a common complication of kidney transplantation, fully exploration of the risk factors and timely prevent and the corresponding comprehensive treatment is the key to the success of kidney transplantation.
OBJECTIVE: To investigate the cause and treatment of DGF after kidney transplantation.
METHODS: A retrospective analysis was preformed on 108 cases of DGF after kidney transplantation who admitted in Department of Nephropathy, Affiliated Hospital of Logistics University of Chinese People’s Armed Police Forces from December 2000 to January 2011. All the 108 patients received cadaveric kidney transplantation and corresponding treatment. The clinical effects were observed and the comprehensive analysis of the reasons for DGF was analyzed.
RESULTS AND CONCLUSION: In the 108 patients with DGF, the causes were acute rejection episode in 52 cases (48.2%), acute renal tubular necrosis in 45 cases (41.5%), graft artery anastomotic stenosis in 5 cases (4.6%), ureteral obstruction in 3 cases (2.8%) and acute cyclosporine anephrotoxicety in 5 cases (5.6%). The renal function became normal in 89 patients; serum creatinine returned to 200 μmol/L or so in 12 cases; there were 2 cases died of pulmonary infection after using antilymphocyte globulin while 5 cases resumed dialysis with failure to methylprednisolone treatment. Acute rejection and acute renal tubular necrosis are the main reasons for DGF and the combined therapeutic measure should be taken.