Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (16): 2913-2916.doi: 10.3969/j.issn.1673-8225.2012.16.015

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Preparation and characterization of a new-type thermal-sensitive polylactic acid microsphere

Peng Kun1,2, Wang Yuan-liang1, Gan Xiao-ling2, Wang Yi-zhen2, Ruan Chang-shun1, Zhang Jing-wen2, Wang Shu2, Sun Shuang-ling2, Chen Jun-yi2   

  1. 1Research Centre of Biomaterial and Bionic Engineering, Bioengineering College of Chongqing University, Chongqing  400030, China; 2Department of Medical Technology, Chongqing Medical and Pharmaceutical College, Chongqing  401331, China
  • Received:2011-10-15 Revised:2012-03-09 Online:2012-04-15 Published:2012-04-15
  • Contact: author: Wang Yuan-liang, Professor, Department of Research Centre of Biomaterial and Bionic Engineering, Bioengineering College of Chongqing University, Chongqing 400030, China wyl@cqu.edu.cn
  • About author:Peng Kun★, Master, Lecturer, Research Centre of Biomaterial and Bionic Engineering, Bioengineering College of Chongqing University, Chongqing 400030, China; Department of Medical Technology, Chongqing Medical and Pharmaceutical College, Chongqing 401331, China pk3001@163.com

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Abstract:

BACKGROUND: At present, the research of controlled drug release has been focused on intelligent microspheres based on polylactic acid.
OBJECTIVE: To prepare a temperature-controllable and biodegradable microsphere carrier.
METHODS: First, 2-hydroxyethyl methacrylate was used as evocating agent for ring-opening polymerization of lactide, and stannous octoate used as catalyst. Through regulating the proportion of lactide and ethyl methacrylate, a double-bound polylactic acid ethyl methacrylate (PDLLA-EMA) of different molecular masses was obtained. After that, methylbenzene was used as solvent, and the copolymerizations of PDLLA-EMA with double bound and poly N-isopropylacrylamide (PNIPAm) were initiated by free radical reaction with a solution synthesis method, and then the biodegradable and temperature-sensitive     PNIPA-g-PDLLA-EMA was prepared successfully. At last, the thermal-sensitive polylactic acid microspheres were prepared by a double emulsion method.
RESULTS AND CONCLUSION: The thermal sensitive temperature of PNIPA-g-PDLLA-EMA prepared was in a range of   35-42 ℃. The range of microsphere particle size was (13.70±0.70) to (28.90±0.50) μm, and the change rate of particle size was (138.7±4.20)% to (170.0±10.00)%. Compared with other same type materials, this kind of microsphere has potentialities in biomedicine.

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