Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (15): 2776-2779.doi: 10.3969/j.issn.1673-8225.2012.15.025

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Influence of Bu Yang Huan Wu Tang on the expression of aortic vascular cell adhesion molecule 1 mRNA in a rat atherosclerosis model 

Zhang Hong-zhen1, Chen Yan-qing2, Geng Yan-jun3   

  1. 1Department of Integrative Medicine, 2Basis Department, Shanxi College of Traditional Chinese Medicine, Taiyuan  030024, Shanxi Province, China; 3Hospital of Integrated Chinese and Western Medicine of Shanxi Province, Taiyuan  030009, Shanxi Province, China
  • Received:2011-10-20 Revised:2011-11-28 Online:2012-04-08 Published:2012-04-08
  • Contact: author: Chen Yan-qing, Master, Associate chief physician, Basis Department, Shanxi College of Traditional Chinese Medicine, Taiyuan 030024, Shanxi Province, China evidencebased@126.com Corresponding author: Geng Yan-jun, Associate chief nutritionist, Hospital of Integrated Chinese and Western Medicine of Shanxi Province, Taiyuan 030009, Shanxi Province, China gyj4630195@yahoo.com.cn
  • About author:Zhang Hong-zhen★, Master, Associate professor, Department of Integrative Medicine, Shanxi College of Traditional Chinese Medicine, Taiyuan 030024, Shanxi Province, China zhangjieer@sina.com
  • Supported by:

    Scientific and Technological Project of Shanxi Health Department, No.200958*

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Abstract:

BACKGROUND: Gene expression product of vascular cellular adhesion molecule-1 (VCAM-1) mRNA plays an important role in atherosclerosis. Bu Yang Huan Wu Tang has the effect of changing the quality of blood rheology, decreasing the level of blood-lipid and against atherosclerosis.
OBJECTIVE: To observe the therapeutic effect of Bu Yang Huan Wu Tang on the treatment of atherosclerosis model, meanwhile, to investigate the mechanism on molecule level.
METHODS: High fat diet and Vitamin D3 were used to induce a rat atherosclerosis model. After the AS rats model establishement, thirty-two rats model were divided into four groups according to random touch ball method: Bu Yang Huan Wu Tang therapy group, ligustrazine therapy group, model group and normal control group. The level of blood lipid and the expression of VCAM-1 mRNA in each group were observed.
RESULTS AND CONCLUSION: The rate of molding success was 92%. The level of blood lipid in Bu Yang Huan Wu Tang therapy group was close to normal level, and there was no significant difference when compare with other two groups. There was no expression of VCAM-1 mRNA in normal control group, and compared with ligustrazine therapy group and model group, the expression of VCAM-1 mRNA in Bu Yang Huan Wu Tang therapy group was decreased significantly. It indicates that representative formula of qi-benifiting and blood-activating Chinese medicinal herbs Bu Yang Huan Wu Tang can down-regulate the expression of VCAM-1 mRNA, and decrease the level of blood-lipid in rat models. It has the effect against atherosclerosis, and the mechanism may be related with the down-regulated expression of VCAM-1mRNA.
Zhang HZ, Chen YQ, Geng YJ. Influence of Bu Yang Huan Wu Tang on the expression of aortic vascular cell adhesion molecule 1 mRNA in rat atherosclerosis model. Zhongguo Zuzhi Gongcheng Yanjiu. 2012;16(15): 2776-2779.    
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