Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (14): 2621-2624.doi: 10.3969/j.issn.1673-8225.2012.14.030

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Application and prospects of bone marrow mesenchymal stem cells and cytokines in the treatment of femoral head necrosis 

Zuo Si-li, Gong Yue-kun   

  1. Department of Orthopedics, First Affiliated Hospital of Kunming Medical University, Kunming  650032, Yunnan Province, China
  • Received:2011-10-27 Revised:2011-11-13 Online:2012-04-01 Published:2012-04-01
  • Contact: author: Gong Yue-kun, Doctor, Master’s supervisor, Professor, Chief physician, Department of Orthopedics, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China
  • About author:Zuo Si-li★, Studyig for master’s degree, Physician, Department of Orthopedics, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China zuosili@126.com

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Abstract:

BACKGROUND: Simple application of bone marrow mesenchymal stem cells (BMSCs) to treat femoral head necrosis has a poor effect, Addition of cytokines during BMSCs application plays a better role.
OBJECTIVE: To summarize the application of BMSCs induced by related cytokines on the treatment of femoral head necrosis.
METHODS: The PubMed database and Wanfang database from 1989 to 2009 were searched by the first author. The articles were related to the new progress in the treatment of femoral head necrosis, the application of BMSCs on the treatment of bone-related diseases, the related cytokines which could induce BMSCs to differentiate into osteoblasts and the underlying mechanism.
RESULTS AND CONCLUSION: The cytokines such as bone morphogenetic proteins, osteogenic growth peptide, vascular endothelial growth factor, cartilage-derived morphogenetic protein 1, transforming growth factor β, insulin-like growth factor-1, platelet-derived growth factor could induce the BMSCs to differentiate into osteoblasts and chondrocytes, and could promote the recovery of callus. Thus, the clinical application of cytokine induced BMSCs could optimize the treatment of femoral head necrosis. 

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