Abstract:

BACKGROUND: Bone marrow stromal stem cells transplantation has become one of the most perspective methods to solve the problem of cartilage tissue defects, and bone marrow stromal stem cells have become the important seed cells to repair the cartilage tissue defects.
OBJECTIVE: To analyze the application of bone marrow stromal stem cells on meniscus injury and cartilage injury, in order to provide the theory reference for the repair and treatment of knee meniscus injury.
METHODS: The PubMed database and Tongfang database 1997/2011 were retrieved by the first and second authors with the key words “Bone Marrow Stromal Cells; Knee Joint Meniscus Injury” in English and Chinese. A total of 26 articles related to bone marrow stromal stem cells for repair of the knee meniscus injury were included to analysis.
RESULTS AND CONCLUSION: Bone marrow stromal cells in the repair and treatment of knee meniscus injury have unique advantages, including less damage surface, convenient and easy to operate, no complications, and no changes in morphology and biological function caused by the removal of the meniscus, and without load conduction disorders and caused by allogeneic material transplantation and the possibility of late onset osteoarthritis. The treatment concept of bone marrow stromal stem cells transplantation was close to meniscus injury, and became the new ideas in the current and future treatment and repair of knee meniscus injury. During the process of repair treatment, the key was how to obtain a large amount of purified bone marrow stromal stem cells and induce into the meniscus cartilage phenotype in vitro. The exact mechanism underlying induction of differentiation should be further investigated.