Abstract:

BACKGROUND: Biological patch is an important substitute of pelvic floor tissue, which can replace the impaired pelvic fascia tissue and has been widely used in pelvic floor reconstruction, but its efficacy and biocompatibility remain poorly studied.
OBJECTIVE: To study the clinical application and biocompatibility of biological patch in obstetrics and gynecology disease.
METHODS: An online computer-based retrieval of PubMed database and VIP database between January 1990 and December 2011 was performed for articles related to clinical application and biocompatibility of biological patch in obstetrics and gynecology disease. English key words were “obstetrics, gynecology diseases, treatment”, and Chinese key words were “patch, gynecologic and obstetric diseases, treatment”. A total of 192 literatures were screened, and 22 documents were eventually involved in the analysis.
RESULTS AND CONCLUSION: Pelvic floor tissue substitutes for pelvic floor repair and reconstruction can replace the impaired pelvic fascia tissue, and can be divided into biological materials and synthetic materials. A variety of repairing materials have their advantages and disadvantages. In all types of implants, autologous tissue, allograft and xenograft are prone to infection, abrasion, poor biocompatibility after implantation, so they are not applicable as the reconstruction materials. The synthetic absorbable patch is strong, easy to use, but prone to infection, rejection and erosion, showing a poor biocompatibility. Synthetic nonabsorbable patch and acellular patch have low infection rate, few complications, and good biocompatibility. A large-size prospective case-controlled study for a longer follow-up visits are required to determine which kinds of patch materials are optimal and how is long-term efficacy results.