Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (12): 2237-2240.doi: 10.3969/j.issn.1673-8225.2012.12.034

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Biocompatibility of chitosan

Li Ruo-hui, Zhang Xue, Shan Dan-tong, Yuan Zhi-kui   

  1. Biochemical Engineering College of Beijing Union University, Beijing  100023, China
  • Received:2011-09-10 Revised:2011-10-14 Online:2012-03-18 Published:2012-03-18
  • About author:Li Ruo-hui★, Master, Associate professor, Biochemical Engineering College of Beijing Union University, Beijing 100023, China ruohui27@sina.com
  • Supported by:

    Research Grants Program of Beijing Municipal Education Commission, No. KM200811417015*

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Abstract:

BACKGROUND: Chitosan is a kind of nature polysaccharide which recently has been widely applied in biomedical field as its unique alkaline and positive charges that are critically depending on its biocompatibility.
OBJECTIVE: To summarize the biocompatibility of chitosan as well as its histocompatibility, blood compatibility and mechanical compatibility.
METHODS: The databases of PubMed, CNKI and Wanfang (1990-2011) were used to search the related articles about the biocompatibility of chitosan and its derivant and the applications on biomedicine. 
RESULTS AND CONCLUSION: Chitosan as a kind of biodegradable polymer materials has been gradually applied on artificial skin, operation suture, ophthalmology, artificial skeleton, oral rehabilitation and tumor therapy depended on its good histocompatibility and mechanical compatibility which was used to match human body organization. However, the blood compatibility of chitosan was poor due to its thrombosis. To date, many studies are focus on the solution to this problem, improve the blood compatibility and expand the application on biomedicine filed in order to make it more safety and effectively to contact with cardiovascular system.

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