Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (10): 1869-1892.doi: 10.3969/j.issn.1673-8225.2012.10.039

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Research progress in mesenchymal stem cells transplantation for treatment of multiple sclerosis

Liu Ying, Hou Zong-liu   

  1. Central Laboratory, Yan’an Affiliated Hospital of Kunming Medical University, Kunming  650051, Yunnan Province, China
  • Received:2011-08-03 Revised:2011-11-02 Online:2012-03-04 Published:2012-03-04
  • Contact: Liu Ying★, Studying for master’s degree, Central Laboratory, Yan’an Affiliated Hospital of Kunming Medical University, Kunming 650051, Yunnan Province, China liuyinglab2010@163.com
  • About author:Liu Ying★, Studying for master’s degree, Central Laboratory, Yan’an Affiliated Hospital of Kunming Medical University, Kunming 650051, Yunnan Province, China liuyinglab2010@163.com
  • Supported by:

    Key Projects of Social Development of Yunnan Province, No. 2010CA004*

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Abstract:

BACKGROUND: Multiple sclerosis (MS) is a neurodegenerative disease of the central nervous system and has a complex etiology that is not fully understood. The clinical course of MS is heterogeneous, and the traditional therapeutic interventions for MS have not been convincingly shown to change the natural course of the disease.
OBJECTIVE: To summarize the mechanism and application of mesenchymal stem cells transplantation for the treatment of multiple sclerosis and raise some questions that should be settled.
METHODS: Kjmed databases were searched by the first author using key words of “mesenchymal stem cells, encephalomyelitis, autoimmune, experimental, multiple sclerosis” in English from 2000 to 2011. Literatures that related with the mesenchymal stem cells for the treatment of MS were included, and the repetitive researches were excluded.
RESULTS AND CONCLUSION: A total of 104 documents were retrieved, and 33 articles were retained after deleting unrelated and repetitive ones. To date, the research had showed that mesenchymal stem cells were multipotent stem cell with the characteristics of immune regulatory and neuroprotective properties, and had showed the initial therapeutic effect on the treatment of MS.

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