Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (51): 9587-9592.doi: 10.3969/j.issn.1673-8225.2011.51.021

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Cellular compatibility of Fe3O4 nanoparticles

Gong Jun-zuo1, Tu Zhong-qi2, Duan Hong2, Zhou Shao-bing3   

  1. 1Department of Emergence Medicine, North Sichuan Medical College, Nanchong  637000, Sichuan Province, China
    2Department of Orthopedics, West China Center of Medical Sciences, Sichuan University, Chengdu  610046, Sichuan Province, China
    3Key Laboratory of Advanced Material Technology, the Ministry of Education, Southwest Jiaotong University, Chengdu  610046, Sichuan Province, China
  • Received:2011-06-17 Revised:2011-08-25 Online:2011-12-17 Published:2011-12-17
  • Contact: Tu Zhong-qi, Doctor, Doctoral supervisor, Professor, Department of Orthopedics, West China Center of Medical Sciences, Sichuan University, Chengdu 610046, Sichuan Province, China tuchongqi@163.com
  • About author:Gong Jun-zuo★, Master, Lecturer, Department of Emergence Medicine, North Sichuan Medical College, Nanchong 637000, Sichuan Province, China gongjunzuo@ 163.com

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Abstract:

BACKGROUND: Whether as chemotherapy or as a medium of thermotherapy in malignant tumor, the effect and microstructure of Fe3O4 nanoparticles need further studies.
OBJECTIVE: To analyze the cellular compatibility of Fe3O4 nanoparticles and to investigate the application and problems of Fe3O4 nanoparticles as drug carriers in the chemotherapy of malignant bone tumors.
METHODS: According to the evaluate criteria and requirement of GB/T 16886. 5-2003 (Part V: cytotoxicity test in vitro, Biological Evaluation for Medical Instrument), the colloidal solution of Fe3O4 nanoparticles conjugated with cetrimonium bromide or polyethylene glycol or sodium oleate was co-cultured with osteosarcoma UMR-16 cells and human fibroblast cells, respectively, hence to assess the cytotoxicity characteristics.
RESULTS AND CONCLUSION: According the criteria of GB/T16886.5-2003, Fe3O4 nanoparticles conjugated with sodium oleate had good cellular compatibility, whereas, the cellular compatibility of Fe3O4nanoparticles conjugated with cetrimonium bromide was poor, which were not considered as a drug carrier of chemotherapy drug using in clinical practice. Fe3O4 nanoparticles conjugated with polyethylene glycol had a certain cellular compatibility, which needed further studies used as drug carriers.

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