Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (51): 9593-9597.doi: 10.3969/j.issn.1673-8225.2011.51.022

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Biocompatibility of pure titanium implant surface micro-arc oxidation coating

Zhang Qiang1, Wang Jian-ping2, Hu Mei-ling3, Meng Xiang-cai4, Wang Jing4   

  1. 1Department of Prosthodontics, Second People’s Hospital of Changzhi City, Changzhi  046000, Shanxi Province, China
    2First Department of Pulp Disease, Stomatological Hospital of Jiamusi University, Jiamusi  154002, Heilongjiang Province, China
    3Department of Anesthesiology, Third Affiliated Hospital of Harbin Medical University, Harbin  150040, Heilongjiang Province, China
    4Jiamusi University, Jiamusi  154002, Heilongjiang Province, China
  • Received:2011-03-14 Revised:2011-04-30 Online:2011-12-17 Published:2011-12-17
  • Contact: Wang Jian-ping, Master, Chief physician, First Department of Pulp Disease, Stomatological Hospital of Jiamusi University, Jiamusi 154002, Heilongjiang Province, China WJP.1959@163.com
  • About author:Zhang Qiang★, Master, Department of Prosthodontics, Second People’s Hospital of Changzhi City, Changzhi 046000, Shanxi Province, China 13603695015@ 139.com

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Abstract:

BACKGROUND: Biological effects of various pure titanium implant surface micro-arc oxidation coatings are different.
OBJECTIVE: To study the effects of three different micro-arc oxidation coating palatal implant titanium tablets on mouse osteoblast cell proliferation, alkaline phosphatase activity and beta 1-integrin gene expression level.
METHODS: Using international common mice lines (MC3T3-E1), three different coated titanium pieces were used as influencing factors, pure titanium group as control group. MTT method and electron microscopic observation were conducted for cell adhesion and cell proliferation, PNPP was used for determination of alkaline phosphatase activity, RT-PCR method to detect beta 1-integrin expression in mouse osteoblasts.
RESULTS AND CONCLUSION: The MTT value, alkaline phosphatase activity, beta 1-integrin gene expression level and electron microscopic observation showed calcium, phosphorus, magnesium, zinc coated titanium pieces of titanium dioxide had the best biocompatibility, titanium dioxide coating titanium containing calcium containing phosphorus salt was secondary, and titanium dioxide coated titanium slice was the worst. The results showed that mouse osteoblasts on the porous of calcium, phosphorus, magnesium, zinc coated titanium pieces had the best adhesion and proliferative abilities.

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