Abstract:

BACKGROUND: It is a hot research point that immune tolerance to facilitate long-term survival in organ transplantations produced by induction for transplant recipients-receptor chimera receptor, and a number of successful experience and knowledge has been obtained in experimental animal models. The clinical practice also showed that the compared with other relatives, the rejection of husband-wife after organ transplantation is smaller.
OBJECTIVE: To investigate clinical effects of unrelated living donor kidney transplantation (husband to his wife).
METHODS: A retrospective analysis of 7 recipients receiving spousal renal donor transplantation was performed. The ages of donors were 32-58 years old, and the recipients were 31-56 years old. The marriage age was 5-36 years. Four of them had completely identical ABO blood group, 1 case with O-B, 1 case with O-A, and 1 case with A-AB. The lymphocytotoxic cross match test was negative. One antigen mismatch in 1 case, two antigen mismatch in 2 cases, three antigen mismatch in 3 cases, and four antigen mismatch in 1 case. They underwent open approach nephrectomy, left kidney in 6 cases, and 1 case of right kidney. The triple immunosuppressive regimen (cyclosporine A / tacrolimus + mycophenolate mofetil + prednisone) was used to prevent rejection. All recipients and donors were followed up for 3-70 months.
RESULTS AND CONCLUSION: All operations achieved totally success. None suffered surgical complications. The donors experienced a transient rise in serum, blood pressure, urine and renal functions of the donor were normal, recepients/allografts were all survived. Although preoperative tissue typing results were poor, the spouse’s long-term living together leads to the immune tolerance, so the rates of renal allograft rejection were lower, the results were satisfactory. Spouse transplantation had more advantages than of other relatives.