Abstract:

BACKGROUND: Studies demonstrated that hepatitis virus after renal transplantation has more serious hepatic lesion than preoperative infection, and some views have suggested preoperative hepatitis virus infection has little effect on renal function after renal transplantation within 5 years.
OBJECTIVE: To analyze the incidence and treatment of serious hepatitis after renal transplantation.
METHODS: A total of 19 cases with serious hepatitis after kidney transplantation were retrospectively analyzed. The treatment included general treatment, antiviral therapy, adjustment of immunosuppressant protocol, and artificial liver treatment. General state of health, hepatic function, blood routine and death rate of patients after combined therapy were observed.
RESULTS AND CONCLUSION: Totally 19 cases with serious hepatitis underwent conventional therapy and antiviral therapy, a part of 19 cases treated with bilirubin adsorption, 12 cases treated with artificial liver. Spirit and sanity have different degrees of improvement, and bilirubin and transaminase were decreased to some extent. A total of 13 cases died, including 4 cases died who infected hepatitis virus after operation, 3 cases with simple drug induced hepatic lesion were fully recovered. The results suggested that the death rate of serious hepatitis after renal transplantation is high. Patients treated with antiviral therapy and/or artificial liver based on diagnosis of conventional therapy in patients with severe hepatitis, can reverse patients’ condition, may reduce mortality.