Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (5): 800-805.doi: 10.3969/j.issn.1673-8225.2011.05.010

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Evaluation of early nutrition support following liver transplantation

Luo Wen-feng, Shi Jun, Zhou Kai, Ding Li-min, Xu Zhi-dan, Wang Yong-gang, Li Xin-chang, Long Cheng-mei, Luo Lai-bang   

  1. Organ Transplantation Center of Jiangxi Provincial People’s Hospital, Nanchang 330006, Jiangxi Province, China
  • Received:2010-07-12 Revised:2010-11-15 Online:2011-01-29 Published:2011-01-29
  • Contact: Shi Jun, Doctor, Professor, Master’s supervisor, Chief physician, Organ Transplantation Center of Jiangxi Provincial People’s Hospital, Nanchang 330006, Jiangxi Province, China shijun6207@163.com
  • About author:Luo Wen-feng★, Master, Associate chief physician, Organ Transplantation Center of Jiangxi Provincial People’s Hospital, Nanchang 330006, Jiangxi Province, China kelvinf@126.com
  • Supported by:

    the Key Program of Jiangxi Provincial Health Department, No. 200501023*

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Abstract:

BACKGROUND: Most liver transplantation recipients have various degrees of malnutrition before and after surgery. Conventional nutritional support treatments include parenteral nutrition (PN) and enteral nutrition (EN). Nutrition support has been rapidly developing over the past few years, and metabolic intervention nutrition (MIN) has aroused more attention in organ transplantation field.
OBJECTIVE: To investigate the safety, efficacy, and feasible nutritional support treatments at early stage following liver transplantation.
METHODS: A total of 45 recipients undergoing nutritional support treatments at the early stage of liver transplantation (1-7 days post surgery) were randomly assigned to PN, EN, and MIN (EN+glutamine+arginine), with 15 patients in each group. The treatments involved equal heat quantity and nitrogen. The curative effects of three treatments were compared by detections of liver function, nitrogen balance, and postoperative complications.
RESULTS AND CONCLUSION: A total of 45 patients were included in the final analysis. Compared with EN, PN and MIN more effectively improved nutrition condition of recipients and better ameliorated liver functional recovery. Compared with PN, MIN better facilitated nitrogen balance, promoted protein synthesis and liver functional recovery. Results demonstrated that PN and MIN are safe, effective and feasible early nutrition support treatments following liver transplantation.

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