Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (49): 9155-9159.doi: 10.3969/j.issn.1673-8225.2011.49.008

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Safety of umbilical cord versus bone marrow-derived mesenchymal stem cells transplantation for the treatment of nervous system lesions

Huang Huai1, Chen Hui-qiang2, Pang Yan3, Gu Jing1, Yu Rong-hao1, Xiao Yang3   

  1. 1Department of Hyperbaricoxygen, 2Department of Traumatic Orthopedics, 3Department of Hematology, Guangzhou General Hospital of Guangzhou Military Command of Chinese PLA, Guangzhou  510010, Guangdong Province, China
  • Received:2011-03-30 Revised:2011-05-27 Online:2011-12-03 Published:2011-12-03
  • About author:Huang Huai, Associate chief physician, Department of Hyperbaricoxygen, Guangzhou General Hospital of Guangzhou Military Command of Chinese PLA, Guangzhou 510010 , Guangdong Province, China huanghuai1999@163.com
  • Supported by:

    the Science and Technology Program of Guangdong Province in 2010, No. 2010B031600264*

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Abstract:

BACKGROUND: The comparative study concerning the safety of umbilical cord and bone marrow-derived mesenchymal stem cells transplantation for the treatment of nervous system lesions is insufficient. 
OBJECTIVE: To assess the safety of umbilical cord and bone marrow-derived mesenchymal stem cells transplantation for treatment of nervous system lesions.
METHODS: A total of 214 cases with neuropathy were randomly divided into A, B groups. Patients in the A group received umbilical cord derived stem cell transplantation, and those in the B group received bone marrow-derived mesenchymal stem cells transplantation. Totally (5-12)×108 stem cells were transplanted into each patient.
RESULTS AND CONCLUSION: The count of lymphocytes, alanine aminotransferase, aspartate aminotransferase, IgA, and IgM were increased compared with those before treatment in both groups (P < 0.01); However there were no significant differences between two groups (P > 0.05). Moreover, white blood cell count and red blood cell count in cerebrospinal fluid of all patients were significantly greater than the normal level. There were no significant differences between two groups (P > 0.05). No significant differences of the positive rate of Pandy test and the incidence rate of adverse effect were found in both groups (P > 0.05). The safety of umbilical cord and bone marrow-derived mesenchymal stem cell transplantation for treatment of nervous system lesions showed no marked differences.

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