Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (47): 8907-8910.doi: 10.3969/j.issn.1673-8225.2011.47.042

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Relationship of biomaterials related infections and transforming growth factor levels in the peripheral blood of lung cancer patients

Lei Yu-jie1, Huang Yun-chao1, Yang Li2, Guo Feng-li2, Zhao Guang-qiang1, Xu Yu-shan3, Chen Xiao-bo1, Yang Kai-yun1   

  1. 1Department of Cardiothoracic Surgery, 2Clinical Laboratory, Third Affiliated Hospital of Kunming Medical University, Kunming  650118, Yunnan Province, China; 3Department of Endocrinology, First Affiliated Hospital of Kunming Medical University, Kunming  650031, Yunnan Province, China
  • Received:2011-08-04 Revised:2011-08-31 Online:2011-11-19 Published:2011-11-19
  • Contact: Huang Yun-chao, Professor, Doctoral supervisor, Department of Cardiothoracic Surgery, Third Affiliated Hospital of Kunming Medical University, Kunming 650118, Yunnan Province, China
  • About author:Lei Yu-jie☆, Studying for doctorate, Lecturer, Department of Cardiothoracic Surgery, Third Affiliated Hospital of Kunming Medical University, Kunming 650118, Yunnan Province, China huangych2001@ yahoo.com
  • Supported by:

    the National Natural Science Foundation of China, No. 30872555*; the Applied Basic Research Program of Social Developmental Science Plan of Yunnan Science and Technology Bureau, No. 2009ZC116M*

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Abstract:

BACKGROUND: Permanent or transient implantation of biomaterials can result in biomaterials-centered infections (BCI) in lung cancer patients.
OBJECTIVE: To investigate the relationship between BCI and peripheral blood transforming growth factor β1 (TGF-β1) in patients with lung cancer.
METHODS: A total of 248 lung cancer patients undergoing in vivo intravascular catheter indwelling > 7 days were included. Quantitative method was used for intubation, bacteriological culture and paired blood culture, and API Staph strips were adopted for positive patients. While enzyme-linked immunosorbent assay was used to detect TGF-β1 levels in the peripheral blood of patients with lung cancer and 75 healthy volunteers as normal controls.
RESULTS AND CONCLUSION: Among the 248 patients, there were 82 BCI-positive cases, and 166 BCI-negative cases. Thirteen patients were confirmed to have catheter-related bloodstream infection. There were 48 Gram-positive bacteria, 24 Gram-negative bacilli, and 10 fungal. The levels of TGF-β1 were higher in BCI-positive patients than BCI-negative patients (P < 0.05); the levels of TGF-β1 in the BCI-negative group were higher than those in the normal control group (P < 0.05). For lung cancer patients with nosocomial infection induced BCI, there are various species of pathogenic bacteria, and Gram-positive bacteria are more common. To detect TGF-β1 levels in patients with lung cancer is of significance for early prevention of BCI.

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