Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (47): 8879-8882.doi: 10.3969/j.issn.1673-8225.2011.47.035

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Research advances of chitosan nanoparticles as genetic carriers

Li Guang-feng, Yang Jian-dong   

  1. Department of Orthopaedics, Clinical Medical College of Yangzhou University, Yangzhou  225001, Jiangsu Province, China
  • Received:2011-05-20 Revised:2011-08-18 Online:2011-11-19 Published:2011-11-19
  • Contact: Yang Jian-dong, Doctor, Associate chief physician, Department of Orthopaedics, Clinical Medical College of Yangzhou University, Yangzhou 225001, Jiangsu Province, China yangjiandong69@sohu.com
  • About author:Li Guang-feng★, Studying for master’s degree, Physician, Department of Orthopaedics, Clinical Medical College of Yangzhou University, Yangzhou 225001, Jiangsu Province, China wudi19840315@163.com
  • Supported by:

    the National Natural Science Foundation of China, No. 81071466*

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Abstract:

BACKGROUND: In recent years, studies of chitosan as a genetic carrier multiplied for its own characteristics have been increased gradually.
OBJECTIVE: To review the research advances of chitosan nanoparticles as a genetic carrier, and to further improve the effect of gene therapy.
METHODS: Web of Science and CNKI databases were searched (2000-01/2011-04) with the key words of “chitosan, gene” in English and Chinese, respectively. 120 articles related to gene carrier and chitosan were selected firstly, and finally 31 articles were included in result analysis.
RESULTS AND CONCLUSION: Chitosan gene nanoparticle as the non viral gene carrier will play a vital role in this field in the future. Research of chitosan genetically modified system will be more deeply. How to mark, visually track the process of chitosan DNA complex into different cells, make the genetic carrying mechanism clear, improve efficiency, make gene therapy into clinical application as soon as possible will be the main research points in the future.

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