Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (47): 8809-8812.doi: 10.3969/j.issn.1673-8225.2011.47.017

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Histocompatibility of implantable glucose sensor membrane materials: Comparison of chitosan and Nafion

Liu Bo-ji, Sha Xian-zheng   

  1. Department of Biomedical Engineering, China Medical University, Shenyang  110001, Liaoning Province, China
  • Received:2011-05-19 Revised:2011-06-26 Online:2011-11-19 Published:2011-11-19
  • Contact: Sha Xian-zheng, Professor, Department of Biomedical Engineering, China Medical University, Shenyang 110001, Liaoning Province, China xzsha@ mail.cmu.edu.cn
  • About author:Liu Bo-ji★, Studying for master’s degree, in China Medical University, now working in Radiation Therapy Center of Sun·Yat-sen University Cancer Center, Guangzhou, 510060, Guangdong Province, China liuboji85@163.com
  • Supported by:

    the Natural Science Foundation of Liaoning Province, No. 201102289*

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Abstract:

BACKGROUND: Chitosan is a natural polysaccharide polymer, and can be applied alone or combined with other materials to prepare dressings, drugs, gene vectors, biological coatings, tissue engineering scaffolds, sensors membranes, etc.
OBJECTIVE: To determine the soft-tissue histocompatibility of chitosan (CS) and Nafion that can be used to optimize the properties of implantable glucose sensors.
METHODS: CS membrane was prepared, characterized, and subcutaneously implanted to investigate the biodegradation property in vivo. Muscularly implanted in mice, the histocompatibility of CS was compared with common sensor material Nafion.
RESULTS AND CONCLUSION: The properties of CS membrane could be controlled through preparation techniques. Compared with muscularly implanted, CS membrane subcutaneously implanted resulted in heavier inflammatory reaction and the average degradation rate was (17.0±9.9)% at 63 days after subcutaneously implanted. The fibrous capsule (FC) thickness was comparable with no statistic difference (P > 0.05) for CS and Nafion, and both became stable after 15 days. Compared with muscularly implanted, FC thickness of CS subcutaneously implanted was thicker. As a result, it is proved that CS and Nafion are both biocompatible to be used in implantable glucose sensor.

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