Abstract:

BACKGROUND: Recently, the research and clinical application of drug-eluting stents continue to expand, so that coronary stent restenosis rate is significantly reduced, and the drug-eluting stents in the prevention of restenosis compared with bare stents has a unique value.
OBJECTIVE: To explain the clinical application of drug-eluting stents, and to explore the stent coating materials, stent types and correlation with restenosis after implantation, and compatibility with the host.
METHODS: A computer search of CNKI and Medline was performed using keywords of “coronary stents, metal stents, drug-eluting stents, restenosis”. Meta-analysis or repetitive articles were excluded, and 27 articles were included in result analysis.
RESULTS AND CONCLUSION: Drug-eluting stents is indeed a major breakthrough in interventional cardiology, but its long-term effect remains to be seen. Various drug-eluting stents containing different drugs in different concentrations, and their mechanisms are distinct as well as the drug release rates, so clinical effectiveness and safety of drug-eluting stents need the rigorous and extensive clinical studies. Today, stent carrier materials can age, loss, and form small tissues in blood vessels, resulting in late adverse reactions. Biodegradable materials as drug carrier materials are possible to reduce the appearance of late adverse reactions. Therefore, the development of an ideal stent system mainly focuses on low-inflammatory biodegradable polymer materials and efficient drug delivery system.