Abstract:

BACKGROUND: Choice of graft materials for brain injury repair is still controversial, and so far no single material can completely replace the skull in the physical and chemical nature.
OBJECTIVE: To conclude the effect and properties evaluation of different intracranial implant materials on brain injury repair.
METHODS: A computer based search of CNKI and PubMed (1993-01/2010-11) was performed for relevant articles. The keywords were “traumatic brain injury, compound material, biological material, damage repair” in Chinese and English, respectively. Repetitive articles and Meta analysis were excluded.
RESULTS AND CONCLUSION: Finally, 24 articles were included in result analysis. There are three kinds of repair materials for skull defects: autologous and allogeneic bone graft, non-metallic materials, metal-generation materials. Autologous and allogeneic bone graft is not good at shaping, and there is absorption of immune rejection and necrosis. Titanium mesh materials as an ideal material for cranioplasty can shorten surgical time and reduce the corresponding complications by using three-dimensional digital skull shaping technology, which realize individual configurations to achieve the repair of skull defects. Titanium alloy has good biocompatibility, high strength, not aging, low density, no influence on CT/MRI, electroencephalogram  and other tests; after titanium alloy implantation, fibroblasts may grow into the porous titanium mesh to realize the integration of titanium mesh with surrounding tissues, which significantly reduces the complications.