Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (31): 5835-5838.doi: 10.3969/j.issn.1673-8225.2011.31.032

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Establishment of Diannan small-ear pig models of artificial valve replacement

Huang Dong1, Zhang Gui-min2, Yang Hong-sheng3, Sun Yi2   

  1. 1Department of Cardiothoracic Surgery, Kunming Medical College, Kunming  650000, Yunnan Province, China
    2Department of Cardiac Surgery, First Affiliated Hospital, Kunming Medical College, Kunming  650000, Yunnan Province, China
    3Department of Public Health of Yunnan Province, Kunming  650000, Yunnan Province, China
  • Received:2011-01-05 Revised:2011-05-19 Online:2011-07-30 Published:2011-07-30
  • Contact: Zhang Gui-min, Professor, Chief physician, Department of Cardiac Surgery, First Affiliated Hospital, Kunming Medical College, Kunming 650000, Yunnan Province, China zhshn1990@yahoo. com.cn
  • About author:Huang Dong★, Studying for master’s degree, Department of Cardiothoracic Surgery, Kunming Medical College, Kunming 650000, Yunnan Province, China nikebike@163.com
  • Supported by:

    the National Natural Science Foundation of China, No. 30860279*

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Abstract:

BACKGROUND: The pig’s heart is considered most anatomically similar to the human heart, and therefore is an ideal model for studying cardiovascular diseases.
OBJECTIVE: To establish Diannan small-ear pig models of mitral valve replacement and investigate the feasibility of model establishment by cardiac ultrasonography.
METHODS: Ten adult pigs underwent mitral valve replacement via the left atrial appendage under cardiopulmonary bypass through three replacement models. At 2 weeks after replacement, changes in cardiac structure and function were analyzed using cardiac ultrasonography.
RESULTS AND CONCLUSION: One pig died for cardiopulmonary arrest during anesthesia induction. The remaining nine pigs survived after surgery. Cardiac ultrasonography showed that at 2 weeks after transplantation, there was no significant difference in cardiac structure and function compared with prior to transplantation, artificial valve showed good hemodynamics and histocompatibility in the pig’s body, and before and after transplantation, pig’s cardiac structure and function were stable.

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