Early analgesia of cocktail therapy after total knee arthroplasty with enhanced recovery after surgery program

doi:10.3969/j.issn.2095-4344.3826

Abstract

Abstract: BACKGROUND: Although cocktail therapy is widely used to relieve pain after total knee arthroplasty, the analgesic effect of different combination schemes has not been fully confirmed.
OBJECTIVE: To observe the efficacy of cocktail therapy on analgesia after total knee arthroplasty with enhanced recovery after surgery program.
METHODS: Sixty patients with severe knee osteoarthritis who underwent unilateral total knee arthroplasty at Tianjin Hospital from January to May 2019 were enrolled. According to the principle of double-blind randomization, they were divided into two groups, 30 cases in each group. Patients in the trial group were injected with cocktail formula drugs around the joints in the operation, while patients in the control group did not receive any treatment. Static pain visual analogue scale scores of knee joints at 6, 12, 24, 48, and 72 hours, the maximum flexion of the knee joint at 48 and 72 hours, the initial time of the straight leg-raising, and postoperative opioid remedy analgesia rate and postoperative complications were compared between the two groups.
RESULTS AND CONCLUSION: (1) The visual analogue scale scores of the trial group were significantly lower than those of the control group at 6 and 12 hours after operation (both P < 0.001), and the postoperative analgesic rate of opioids was significantly lower in the trial group than that of the control group (P < 0.001). (2) There were no statistically significantly differences in the preoperative general data, visual analogue scale scores at 24, 48, and 72 hours, knee maximum flexion at 48 and 72 hours, the time of the straight leg-raising, and postoperative complications (both P > 0.05). (3) The results indicate that cocktail therapy in total knee arthroplasty is safe and effective for early postoperative analgesia with enhanced recovery after surgery program.

Key words: total knee arthroplasty, cocktail therapy, analgesia, enhanced recovery after surgery program, complication

CLC Number:

Li Shangzhi, Zheng Dezhi, Liu Jun. Early analgesia of cocktail therapy after total knee arthroplasty with enhanced recovery after surgery program[J]. Chinese Journal of Tissue Engineering Research, 2021, 25(18): 2794-2798.

Figures/Tables 4

References

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