Bradykinin B2 receptor gene polymorphisms influence the susceptibility of knee osteoarthritis

doi:10.3969/j.issn.2095-4344.2015.51.002

Chinese Journal of Tissue Engineering Research ›› 2015, Vol. 19 ›› Issue (51): 8208-8212.doi: 10.3969/j.issn.2095-4344.2015.51.002

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Bradykinin B2 receptor gene polymorphisms influence the susceptibility of knee osteoarthritis

Feng Hui¹, Feng Hu², Guo Kai-jin², Chen Shuo³, Yuan Feng²

¹Graduate School of Xuzhou Medical College, Xuzhou 221000, Jiangsu Province, China;²Department of Orthopedics, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221000, Jiangsu Province, China; ³Department of Orthopedics, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, Jiangsu Province, China

Received:2015-10-28 Online:2015-12-10 Published:2015-12-10
Contact: Yuan Feng, M.D., Chief physician, Department of Orthopedics, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221000, Jiangsu Province, China Corresponding author: Chen Shuo, M.D., Attending physician, Department of Orthopedics, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, Jiangsu Province, China
About author:Feng Hui, Studying for Master’s degree, Attending physician, Graduate School of Xuzhou Medical College, Xuzhou 221000, Jiangsu Province, China
Supported by:
the National Natural Science Foundation of China, No. 81301582; Military Medical Development
Project for the Youth, No. 13QNP044; China Postdoctoral Science Foundation, No. 2015M572812; the Clinical Medicine Scientific Special Fund of Jiangsu Province, No. BL2012002

Abstract

Abstract:

BACKGROUND: It has been reported that bradykinin B2 receptor (BDKRB2) antagonists can produce long-lasting analgesic effect in patients with knee osteoarthritis, and BDKRB2 plays an important role in the development of osteoarthritis.
OBJECTIVE: To further verify the association BDKRB2 polymorphisms and osteoarthritis susceptibility.
METHODS: 278 patients with primary knee osteoarthritis and 291 healthy volunteers as controls were enrolled. BDKRB2 gene polymorphisms were genotyped.
RESULTS: The genotype distributions and allele frequencies of +9/-9 bp polymorphisms significantly differed between osteoarthritis patients and healthy controls. The -9/-9 polymorphisms were significantly associated with the increased risk and the radiographic severity of knee osteoarthritis compared to the +9/+9 genotype. The presence of -9 bp was associated with higher Kellgren-Lawrence grade in knee osteoarthritis. These findings suggest that the +9/-9 bp polymorphisms of BDKRB2 gene may be used as a molecular marker for the susceptibility and severity of knee osteoarthritis.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

CLC Number:

R318

Feng Hui, Feng Hu, Guo Kai-jin, Chen Shuo, Yuan Feng . Bradykinin B2 receptor gene polymorphisms influence the susceptibility of knee osteoarthritis [J]. Chinese Journal of Tissue Engineering Research, 2015, 19(51): 8208-8212.

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Bradykinin B2 receptor gene polymorphisms influence the susceptibility of knee osteoarthritis

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