Mesenchymal stem cells promote articular cartilage repair and regeneration

doi:10.3969/j.issn.2095-4344.2015.50.028

Abstract

Abstract:

BACKGROUND: After articular cartilage injury, the injured cartilage almost has no self-healing ability. Articular cartilage injury repair has been always a difficulty in clinical work.
OBJECTIVE: To explore the types and biological characteristics of stem cells for articular cartilage repair and to ensure the role and relative merits of stem cell transplantation in articular cartilage repair.
METHODS: PubMed and CNKI were retrieved by the first author for relevant articles published from 1998 to 2015 using the keywords of “articular cartilage injury, mesenchymal stem cells, regeneration” in English and Chinese, respectively. Finally, 47 articles were included in result analysis.
RESULTS AND CONCLUSION: Stem cell therapy is the most effective method for repair of articular cartilage injury. Mesenchymal stem cells from bone marrow, adipose and umbilical cord have strong chondrogenic and cloning capacities. Bone marrow mesenchymal stem cells have a stronger differentiation potential, and can be used for repair of cartilage injury. Umbilical cord-derived mesenchymal stem cells have a low tumorigenicity. Adipose-derived stem cells can proliferate and grow faster. Stem cells combined with natural carrier materials, such as collagen, gelatin, fibrin and alginate, can promote cell adhesion, differentiation and proliferation, in order to build an effective tissue engineered cartilage for repair of articular cartilage defects.

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

CLC Number:

R394.2

Zhu Yu-qi, Wang Jin-rong, Wang Zhi-yao. Mesenchymal stem cells promote articular cartilage repair and regeneration[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(50): 8195-8200.

Figures/Tables 1

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