Bone cement combined with zoledronic acid to repair osteoporotic vertebral compression fractures

doi:10.3969/j.issn.2095-4344.2015.25.001

Abstract

Abstract:

BACKGROUND: Percutaneous vertebroplasty with bone cement injection for osteoporotic vertebral compression fractures can quickly relieve pain and increase vertebral strength, but vertebral re-fractures often occur because of osteoporosis.
OBJECTIVE: To investigate the therapeutic effect of percutaneous vertebroplasty with bone cement injection combined with zoledronic acid in the treatment of osteoporotic vertebral compression fractures.
METHODS: Six patients with osteoporotic vertebral compression fractures were enrolled, including two males and four females, aged 60-86 years. These patients with T12-L4 vertebral fractures underwent percutaneous vertebroplasty with polymethyl methacrylate acrylate bone cement treatment. At 4 weeks after bone cement injection, all patients were administrated with intravenous injection of zoledronic acid (100 mL: 5 mg) as anti-osteoporosis treatment, 30 drops per minute, once a year, for consecutive 2 years. The 2-year periodic imaging was performed to observe the clinical efficacy on vertebral compression fractures, bone density and adjacent vertebral fractures.
RESULTS AND CONCLUSION: At 48 hours after bone cement injection, pain symptoms were relieved in the six cases. At the end of 2-year follow-up, fractures healed in all the six cases without delayed union or nonunion, and
there was no bone cement leakage, nerve root compression, dural involvement, needle opening or wound infection and pulmonary embolism; the bone density was significantly higher than that before treatment (P < 0.05), and no adjacent vertebral fractures occurred. These findings indicate that the percutaneous vertebroplasty with bone cement injection combined with zoledronic acid can significantly relieve pain, improve vertebral stability and bone density, and reduce the incidence of adjacent vertebral fractures in patients with osteoporotic vertebral compression fractures.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Methylmethacrylates, Osteoporotic Fractures, Vertebroplasty

CLC Number:

R318

Xue Feng, Ye Yu-song. Bone cement combined with zoledronic acid to repair osteoporotic vertebral compression fractures [J]. Chinese Journal of Tissue Engineering Research, 2015, 19(25): 3937-3941.

Figures/Tables 4

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