Chinese Journal of Tissue Engineering Research ›› 2015, Vol. 19 ›› Issue (24): 3788-3792.doi: 10.3969/j.issn.2095-4344.2015.24.004

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Fast-Fix combined with sodium hyaluronate in meniscal repair under arthroscope 

Wu Jian-wei, Fan Guo-feng, Zhang Tian-yi, Qiao Jin-huan, Lu Bo, Kong Fan-lin, Wang Zeng-li   

  1. Department of Orthopedics, CNPC Central Hospital, Langfang 065000, Hebei Province, China
  • Online:2015-06-11 Published:2015-06-11
  • Contact: Qiao Jin-huan, chief physician, Department of Orthopedics, CNPC Central Hospital, Langfang 065000, Hebei Province, China
  • About author:Wu Jian-wei, Department of Orthopedics, CNPC Central Hospital, Langfang 065000, Hebei Province, China

Abstract:

BACKGROUND: Sodium hyaluronate is a polysaccharide polymer biomaterial, which is considered to have a certain effect to repair the cartilage surface, reduce the release of inflammatory mediators, and promote meniscal repair.
OBJECTIVE: To observe the therapeutic effect of Fast-Fix combined with sodium hyaluronate in meniscal repair under arthroscope.
METHODS: Eighty-six patients with meniscus injury admitted at the Department of Orthopedics, CNPC Central Hospital, from March 2008 to March 2014 were enrolled in the study. The average age was 25.5 years, and the average duration of disease was 1.5 months. The main clinical manifestations included knee joint pain and swelling after exercise and positive McMurray signs. The MRI results showed meniscus tear or degeneration. Arthroscopic repairing surgeries were performed with Fast-Fix combined with sodium hyaluronate injection
(2.5 mL at the end of surgery), and then sodium hyaluronate was injected intraarticularly at 1, 2, 3 weeks after surgery. Each patient was assessed with Lysholm knee joint score system before and after operation.
RESULTS AND CONCLUSION: Eighty-one patients were followed up for an average of 1.5 years and five patients were lost to follow-up. Joint locking, significant tenderness and movement disorder symptoms disappeared in 79 of 81 patients, and meniscal healing was shown on MRI review within 1 year after surgery; the Lysholm score was higher than 75 points, and the excellent rate was 98%. Only the remained two patients felt swelling and tenderness and the movement was slightly restricted when going down or standing up. The Fast-Fix combined with sodium hyaluronate in meniscal repair under arthroscope has good effect and good function of knee joint.


中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程

Key words: Hyaluronic Acid, Menisci, Tibial, Arthroscopy

CLC Number: