Chinese Journal of Tissue Engineering Research ›› 2014, Vol. 18 ›› Issue (42): 6863-6870.doi: 10.3969/j.issn.2095-4344.2014.42.026

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Autograft versus non-irradiated allograft for anterior cruciate ligament reconstruction: a meta-analysis

Wang Yi-lun, Xie Dong-xing, Li Hui, Yang Tuo, Deng Zhen-han, Yang Ye, Zhang Yi, Ding Xiang, Lei Guang-hua   

  1. Department of Orthopedics, Xiangya Hospital of Central South University, Changsha 410008, Hunan Province, China
  • Revised:2014-08-20 Online:2014-10-08 Published:2014-10-08
  • Contact: Lei Guang-hua, M.D., Professor, Chief physician, Doctoral supervisor, Department of Orthopedics, Xiangya Hospital of Central South University, Changsha 410008, Hunan Province, China
  • About author:Wang Yi-lun, Studying for master’s degree, Department of Orthopedics, Xiangya Hospital of Central South University, Changsha 410008, Hunan Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 81272034; grant from Development and Reform Commission of Hunan Province, No. [2013]1199; the Science and Technology Program of Hunan Provincial Science and Technology Bureau, No. 2013SK2018; Doctoral Fund of Ministry of Education of China, No. 20120162110036

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Abstract:

BACKGROUND: Reconstruction of the anterior cruciate ligament has become the gold-standard treatment for an anterior cruciate ligament rupture. Despite the popularity of the procedure, there remains a considerable amount of controversies over whether an autograft or anallograft should be used for primary anterior cruciate ligament reconstruction.
OBJECTIVE: To compare the clinical outcomes of allograft and autograft in primary anterior cruciate ligament reconstruction.
METHODS: Randomized controlled trials concerning autograft versus non-irradiated allograft for anterior cruciate ligament reconstruction were identified from the PubMed/Medline database conducted up to July 12, 2014. These studies were selected independently by two reviewers according to the inclusion and exclusion criteria. Meta-analysis was performed using Revman5.2 software.
RESULTS AND CONCLUSION: A total of 6 randomized controlled trials consisting of 858 cases were included, 441 cases in autograft group and 417 cases in non-irradiated allograft. The results of the meta-analysis indicate no significant difference between autografts and non-irradiated allografts in overall IKDC [relative risk (RR)=1.02, 95% confidence interval (CI) (0.99 to 1.06), P=0.21], degree of laxity [mean difference (MD)=-0.13, 95% CI (-0.29 to -0.02), P=0.09], Lachman test [RR=1.04, 95% CI (0.95 to 1.13), P=0.37], pivot shift test [RR=1.00, 95% CI (0.95 to 1.05),P=0.96], one-leg hop test [RR=1.01, 95% CI (0.96 to 1.06), P=0.77], Lysholm score [MD=-0.64, 95% CI (-1.45 to 0.17), P=0.12], Tegner score [MD=0.16, 95% CI (-0.16 to 0.47), P=0.34] and rate of postoperative complications [RR=1.42, 95% CI (0.67 to 3.04), P=0.36]. Therefore, in the meta-analysis, there is no significant difference between autograft and non-irradiated allograft in clinical outcomes. However due to the limitations of our study, further work is needed to determine this conclusion.



中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程


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Key words: anterior cruciate ligament, tendons, transplantation, autologous, transplantation, homologous, evidence-based medicine

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