Predicting deep venous thrombosis using Wells scoring system combined with D-dimer and fibrin degradation product

doi:10.3969/j.issn.2095-4344.2014.38.012

Abstract

Abstract:

BACKGROUND: Diagnosis of deep venous thrombosis has been reported in the literatures, but whether the combination with risk prediction scoring system and a variety of laboratory index increase the diagnosis rate of deep venous thrombosis remains unclear.
OBJECTIVE: To improve the diagnosis sensitivity of traumatic deep venous thrombosis of lower extremity using Wells scoring system combined D-dimer and fibrin degradation product.
METHODS: A total of 82 patients with low limb fractures and spine fracture were included in this study, those patients with high risk factors of deep venous thrombosis or with the history of deep venous thrombosis were excluded. After admission, the following indicators of deep venous thrombosis were determined, including D-dimer, fibrin degradation product, fibrinogenase, prothrombin time, activated partial thrombokinase time, blood platelets count, C-reaction protein, and erythrocyte sedimentation rate. In addition, Doppler ultrasound detection of double lower limbs deep vein was performed, and the results were recorded. According to scoring system of deep venous thrombosis of lower extremity (Wells scoring system), the patients were assigned into low-risk, middle-risk and high-risk cases.
RESULTS AND CONCLUSION: Doppler ultrasound detection showed that, there were 30 cases in deep venous thrombosis group, and 52 cases in non-deep venous thrombosis. The peak value of D-dimer and fibrin degradation product showed significant differences between the two groups (P < 0.05). According to Wells scoring system, there were 13 low-risk cases, 32 middle-risk cases, and 37 high-risk cases. The diagnosis rate of deep venous thrombosis using D-dimer and fibrin degradation product: positive prediction value for middle-risk deep venous thrombosis was 44.44% and for high-risk deep venous thrombosis was 70.97%. Logistic regression analysis showed that, in the middle-risk and high-risk deep venous thrombosis cases, the Wells score has a positive correlation with laboratory test and Doppler ultrasound detection of deep venous thrombosis (P < 0.05). The score of Wells scoring system combined D-dimer and fibrin degradation product have clinical significances for the formation of deep venous thrombosis of lower extremity after trauma.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

全文链接：

Key words: deep venous thrombosis, prediction, fibrin fibrinogen degradation products

CLC Number:

R318

Shen Ming-quan, Xie Zeng-ru. Predicting deep venous thrombosis using Wells scoring system combined with D-dimer and fibrin degradation product[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(38): 6136-6140.

Figures/Tables 2

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