Replantation of inactivated tumor segment boiled in 70 ℃ distilled water for 15 minutes in the treatment of proximal fibular tumors

doi:10.3969/j.issn.2095-4344.2014.08.023

Abstract

Abstract:

BACKGROUND: Apart from a complete resection of tumor tissues, the therapeutic goal for bone tumors is to maximize the repair and restoration of tissue defects and damaged functions. Autologous inactivated bone graft is of practical value for transplantation and reconstruction.
OBJECTIVE: To investigate the effect of improved Malawer method combined with replantation of inactivated tumor segment in the treatment of proximal fibular tumors.
METHODS: Since 2007, five patients with proximal fibular tumors (six sides) were admitted in the Affiliated Hospital of Inner Mongolia Medical University. These five patients were subjected to distal femoral amputation, intralesional curettage and bone grafting, upper fibular osteotomy + tumor segment heating (boiling in 70 ℃ distilled water for 15 minutes) + inactivated bone replantation. Therapeutic effects were followed.
RESULTS AND CONCLUSION: One case of amputation had no recurrence and systemic metastasis during 4 years of follow-up; one case of intralesional curettage and bone grafting relapsed 1 year after operation; three cases of upper fibular osteotomy + tumor segment heating + inactivated bone replantation followed for 5 months recovered walking function and exhibited good healing of the outer structure of the knee, showing non-healing of inactivated tumor segment, non-remarkable callus formation, no local tumor recurrence, no loosening of internal fixation, and inactivated bone without fracture and absorption. These results confirmed that the tumor curettage and amputation both have obvious limitations; based on Malawer method, the replantation of inactive tumor segment can better ensure the structure integrity of the lower leg and in suit reconstruct the lateral biceps femoris tendon and the lateral collateral ligament, but genetically the revascularization and healing of inactivated bones will be difficult and slow with temperature increases, and therefore the period of postoperative brace protection should be relatively extended, allowing time delay of strenuous exercise and avoiding complications such as fractures.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

全文链接：

Key words: bone neoplasms, fibula, osteotomy, bone transplantation

CLC Number:

R318

Bao Yi-min, Zhang Guo-liang, Du Pei-jin, Wang Yue-wen. Replantation of inactivated tumor segment boiled in 70 ℃ distilled water for 15 minutes in the treatment of proximal fibular tumors[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(8): 1289-1294.

Figures/Tables 4

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