Human leukocyte antigen-G and prognosis of liver transplantation in patients with hepatocellular carcinoma

doi:10.3969/j.issn.2095-4344.2013.05.010

Abstract

Abstract:

BACKGROUND: Human leukocyte antigen-G is a kind of nonclassical human leukocyte antigen Ⅰ gene, which has participated in a variety of pathophysiological processes, especially plays an important role in tumor immune escaping. In addition, it may be one of the mechanisms underlying tumor recurrence and metastasis.
OBJECTIVE: To investigate the expression of human leukocyte antigen-G in hepatocellular carcinoma and its significance in the prognosis of liver transplantation in patients with hepatocellular carcinoma.
METHODS: The clinical data of 109 patients who had undergone liver transplantation for hepatocellular carcinoma were analyzed retrospectively. The expression of human leukocyte antigen-G in the hepatocellular carcinoma tissue and liver tissue around the hepatocellular carcinoma tissue was detected with immunohistochemical method. The postoperative follow-up was performed. The Kaplan-Meier method was used to calculate the cumulative survival rate and tumor-free survival rate. Log-rank test and Cox regression model were used to analyze the single and multi-factor for tumor-free survival rate respectively.
RESULTS AND CONCLUSION: The positive expression of human leukocyte antigen-G in tumor tissues was detected in the hepatocellular carcinoma tissue of 77 cases and in the surrounding tissues of 20 cases. A significant association was found between the expression of human leukocyte antigen-G and preoperative size of tumor (P < 0.05), vascular invasion (P < 0.05), and pathological differentiation (P < 0.05). Single factor analysis showed that expression of human leukocyte antigen-G (P < 0.01) was the risk factors that could affect the tumor-free survival rates of hepatocellular carcinoma after liver transplantation. Cox regression model analysis showed that expression of human leukocyte antigen-G (P < 0.05) was the independent risk factors of tumor-free survival rate. Human leukocyte antigen-G was highly expressed in hepatocellular carcinoma. The expression of human leukocyte antigen-G in hepatocellular carcinoma tissues was the independent risk factor of tumor-free survival rate of liver transplantation patients for hepatocellular carcinoma. Interventional treatment for human leukocyte antigen-G positive patients and strict selection of indication of liver transplantation for hepatocellular carcinoma can reduce the rate of tumor recurrence.

Key words: organ transplantation, liver transplantation, human leukocyte antigen G, hepatocytes, liver cancer, prognosis, hepatocellular carcinoma tissues, surrounding liver tissues, immunohistochemistry, tumor-free survival rate, risk factor, the National 973 Planning of China, photographs-containing paper of organ transplantation

CLC Number:

R318

Zeng Xian-cheng, Zhang Tong, Chen Wei, Chen Guan-zhong, Li Hua, Zhang Qi. Human leukocyte antigen-G and prognosis of liver transplantation in patients with hepatocellular carcinoma[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(5): 825-831.

Figures/Tables 6

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