Abstract:

BACKGROUND: With the continuous development of the molecular biology, studies on laboratory indicators reflecting the pathological changes of early articular cartilage degeneration have become a hot spot.
OBJECTIVE: To explore clinical significance of type Ⅱ collagen telopeptides and cartilage oligomeric matrix protein in knee osteoarthritis patients, seeking the relativity between them and characteristic rule of primary knee osteoarthrosis.
METHODS: Seventy patients with primary knee osteoarthrosis were enrolled in the experimental group, and 18 healthy volunteers served as control group. Serum type Ⅱ collagen telopeptides and cartilage oligomeric matrix protein levels were detected by enzyme-linked immunosorbent assay method.
RESULTS AND CONCLUSION: The serum type Ⅱ collagen telopeptides and cartilage oligomeric matrix protein levels in the experimental group were significantly higher than those in the control group. There were notable differences among different genders, age and X-ray changes. Stroke musculoskeletal patients with different syndromes of traditional Chinese medicine had lower type Ⅱ collagen telopeptides levels than patients with liver and kidney deficiency as well as vital energy retardation and blood stasis, but no difference was found in cartilage oligomeric matrix protein levels. These findings indicate that type Ⅱ collagen telopeptides and cartilage oligomeric matrix protein have a closely related relationship with the occurrence and development of primary knee osteoarthritis. Combination of type Ⅱ collagen telopeptides and cartilage oligomeric matrix protein can play an important role in the pathogenesis of knee osteoarthritis, have a close relationship with cartilage degeneration and reflect the condition and syndromes of traditional Chinese medicine.

Key words: tissue construction, bone tissue construction, knee osteoarthritis, type Ⅱ collagen telopeptides, cartilage oligomeric matrix proteins, related research, pathogenesis