Different methods for establishing rabbit models of knee osteoarthritis: rational option and characters

doi:10.3969/j.issn.2095-4344.0330

Abstract

Abstract:

BACKGROUND: Animal models have been widely applied in the studies on osteoarthritis. Rabbits are the most commonly used animal models. In many modeling methods, inductive model is preferred because of good stability, high efficiency, and repeatability.
OBJECTIVE: To analyze the research status and application of rabbit models of knee osteoarthritis at home and abroad in recent years.
METHODS: A computer-based search of PubMed, Web of Science, CNKI, WanFang, and VIP databases was performed. The keywords were “animal model, osteoarthritis knee, rabbit” in English and Chinese, respectively. The articles concerning rabbit models of knee osteoarthritis published between August 1983 and December 2017 were retrieved, including reviews, basic researches, and clinical studies. The articles were screened preliminarily by reading the topic and abstract of the screening, and irrelative articles were excluded. Finally 52 articles were enrolled for review according to the inclusion and exclusion criteria.
RESULTS AND CONCLUSION: Animal models of osteoarthritis are mainly divided into spontaneous, inducible, gene knockout types. Inductive models are the most commonly used models in clinical trials, including surgical and non-surgical methods. The anterior cruciate ligament transaction is the commonly used surgical methed, and immobilization model is the most common non-surgical method. The induced model can quickly and steadily cause the pathophysiological changes similar to the degeneration of human knee joint, and the models are mainly used for the studies on the drugs, pathogenesis, and signaling pathways of osteoarthritis. A variety of modeling methods can successfully establish osteoarthritis model, but each has their own advantages and disadvantages, so we should make a reasonable choice in accordance with the experimental design and experimental conditions.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Osteoarthritis, Knee Joint, Models, Animal, Tissue Engineering

CLC Number:

R318

Peng Xu, Xiong Hua-zhang, Yang Ji-bin, You Qi, Jin Ying, Zhang Jun, Ge Zhen, Liu Yi. Different methods for establishing rabbit models of knee osteoarthritis: rational option and characters[J]. Chinese Journal of Tissue Engineering Research, 2018, 22(28): 4550-4556.

Figures/Tables 1

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