Abstract:

BACKGROUND: Aseptic loosening of artificial joints resulted by wear debris caused biological response is the main reason for prosthesis failure. Therefore, to obtain the artificial joints wear debris and to study the biological response is important for the improvement of artificial joint life.
OBJECTIVE: To obtain the nanoscale artificial joints wear debris, and to further study the biological response.
METHODS: The artificial joints wear debris was obtained by acid digestion and enzymatic degradation methods and the separation efficiency of these two methos was compared. Different sizes of particles were obtained and the morphology of nanoparticles was observed.
RESULTS AND CONCLUSION: ①The operation cycle times of total hip simulation testing machine have a certain impact on the size and morphology of ultrahigh molecular weight polyethylene wear debris. ②The distribution range of wear debris particle size was changed from 100 μm to 1 μm. It was feasible to isolate the ultrahigh molecular weight polyethylene wear debris by acid digestion and enzymatic degradation.