Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (22): 4023-4026.doi: 10.3969/j.issn.1673-8225.2012.22.008

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Three anaesthetic drugs in dynamic hip replacement of double hip joint

Lian Ke-jian, Shen Jia-zuo, Lin Da-sheng, Li Da-kun, Li Qiang, Zhang Dong, Li Lin   

  1. Orthopedic Trauma Center of Chinese PLA, 175 Hospital of Chinese PLA (Southeast Hospital of Xiamen University), Zhangzhou  363000, Fujian Province, China
  • Received:2011-10-24 Revised:2012-04-24 Online:2012-05-27 Published:2012-05-27
  • Contact: Shen Jia-zuo, Master, Orthopedic Trauma Center of Chinese PLA, 175 Hospital of Chinese PLA (Southeast Hospital of Xiamen University), Zhangzhou 363000, Fujian Province, China shenjiazuo09@163.com
  • About author:Lian Ke-jian★, Master, Doctoral supervisor, Orthopedic Trauma Center of Chinese PLA, 175 Hospital of Chinese PLA (Southeast Hospital of Xiamen University), Zhangzhou 363000, Fujian Province, China gkxiaohe@163.com

Abstract:

BACKGROUND: Literatures and reports about floret pigs’ anesthesia are rare and the effects of these anaesthetic drugs are not perfect.
OBJECTIVE: To compare the effect of single anaesthetic drug and compounded anaesthetic drugs for floret pig during dynamic hip replacement of double hip joint.
METHODS: Research group brought 18 floret pigs, which were randomly divided into three groups. In the Xylazine group,     0.2 mL/kg Xylazine was injected into musculi colli of floret pig. In Xylazine+Pentobarbital group, 0.2 mL/kg Xylazine compounded with 15 mg/kg Pentobarbital were injected into both musculi colli of floret pig. In Xylazine+Ketamine group, 0.2 mL/kg Xylazine mixed with 10 mg/kg Ketamine were injected into one of musculi colli of floret pig. After the anaesthetic took effects, we had the dynamic replacement of double hip.
RESULTS AND CONCLUSION: Induction period of Xylazine group was longer than that of the other two groups (P < 0.05); anaesthesia period of Xylazine group was shorter than that of the other two groups (P < 0.05); there was no significant difference of recovery period among these three groups (P < 0.05). The respiratory rate of Xylazine+Ketamine group was faster than that of the other two groups (P < 0.05); the heart rate of the Xylazine+Pentobarbital group was faster than that of the other two groups  (P < 0.05); the systolic pressure of Xylazine group and Xylazine+Ketamine group was higher than that of Xylazine+Pentobarbital group (P < 0.05); the shock index of Xylazine+Pentobarbital group was higher than that of the other two groups (P < 0.05). We draw a conclusion that combination anesthesia is better than single-agent anesthesia and recommend that Xylazine mixed with Ketamine is better than Xylazine mixed with Pentobarbital as it has shorter time of anesthesia induction, better effect during maintaining and higher security and waking up quickly, and that is the ideal anaesthetic method.

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