Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (21): 3945-3948.doi: 10.3969/j.issn.1673-8225.2012.21.034

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Research status of folate-conjugated polymer and liposome as targeted drug carriers

Guo Liang, Xiong Xiang-yuan, Li Yu-ping, Li Zi-ling, Gong Yan-chun   

  1. School of Life Science, Jiangxi Science and Technology Normal University, Nanchang 330013, Jiangxi Province, China
  • Received:2011-12-03 Revised:2012-01-12 Online:2012-05-20 Published:2012-05-20
  • Contact: Xiong Xiang-yuan, Professor, School of Life Science, Jiangxi Science and Technology Normal University, Nanchang 330013, Jiangxi Province, China xyxiong@gmail.com
  • About author:Science and Technology Research Project of Jiangxi Provincial Department of Education, No. GJJ10594*
  • Supported by:

    Guo Liang, School of Life Science, Jiangxi Science and Technology Normal University, Nanchang 330013, Jiangxi Province, China xyxiong@gmail.com

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Abstract:

BACKGROUND: Targeted drug carriers mediated by folic acid are studied widely.
OBJECTIVE: To summarize the research status of folate-conjuated polymers and liposomes as targeted drug carriers.
METHODS: The first author searched Web of Science and CNKI for articles (2000-01/2010-12) concerning the folate-conjuated polymers and liposomes as targeted drug carriers with the key words of “folic acid, drug carriers, targeted delivery system, polymer, liposome” in English and “folic acid, drug carriers, targeted, polymer, liposome” in Chinese. Nineteen articles were selected to review.
RESULTS AND CONCLUSION: Folate receptor could overexpressed on the surface of many tumor cells, but the overexpression of folate receptor in the normal tissues is limited to apical membrane of epithelial cells which are difficult to enter the blood circulation. Because of the characteristics of folate receptor expression, natural ligands of folate receptor-folic acid are considered as an important molecule in transfer targeted drugs to tumor cells. Folic acid has the advantages of high affinity and low immunogenicity with folate receptor. Thus researches on folic acid-mediated targeted delivery systems are developed promptly. There are mainly three kinds of folate-modified drug carriers: synthesized polymers, liposomes and natural macromolecules.

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