Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (21): 3941-3944.doi: 10.3969/j.issn.1673-8225.2012.21.033

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Research status and clinical application of biomedical absorable hemostic materials

Zhang Shao-feng1, Hong Jia-yuan2   

  1. 1College of Orthopedics and Traumatology, Fujian University of Traditional Chinese Medicine, Fuzhou  350108, Fujian Province, China; 2Orthopedic Trauma Center, the 175 Hospital of Chinese PLA, Affiliated Southeast Hospital of Xiamen University, Zhangzhou  363000, Fujian Province, China
  • Received:2011-11-12 Revised:2012-01-09 Online:2012-05-20 Published:2012-05-20
  • Contact: Hong Jia-yuan, Master’s supervisor, Associate chief physician, Orthopedic Trauma Center, the 175 Hospital of Chinese PLA, Affiliated Southeast Hospital of Xiamen University, Zhangzhou 363000, Fujian Province, China hongjy175@yahoo.com.cn
  • About author:Zhang Shao-feng★, Studying for master’s degree, College of Orthopedics and Traumatology, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, Fujian Province, China zhangshaofeng017@163.com

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Abstract:

BACKGROUND: Now, various hemostasis materials are developed with different components and mechanisms. Due to their different characteristics, the applications are different.
OBJECTIVE: To review the commonly used clinical absorbable hemostatic materials at home and abroad, and to summarize the composition, hemostatic mechanism and clinical application for guiding clinicians to use them effectively.
METHODS: A computer-based search of CNKI and PubMed databases (2002-02/2011-05) were performed for articles related to hemostatic materials using the key words of “biological material, hemostatic material, bioresorbable material, hemostatic effect, hemostatic mechanism” in Chinese and English, respectively. Literatures on application of biomedical absorbable hemostatic materials were adopted, and others about duplicated study and contents inconsistent with the research purpose were excluded.
RESULTS AND CONCLUSION: Currently, fibrin glue, cellulose, xycellulose, α-cyanoacrylate tissue glue, chitosan and so on are adsorbable hemostasis materials in clinic. The hemostatic reason of chitosan is that the chitosan has some quantitative electric charge, which can directly occur cross linking reaction with the red blood cells on the wound surface to form blood clot, and the hemostasis process is independent of blood coagulation factor and platelet in vivo. Delightfully, α-cyanoacrylate tissue glues not only are used to cardiovascular surgery for small vascular anastomisis, to neurosurgery for repairing cerebral dura mater, to orthopedics for cohereing the fracture and repairing the soft tissues and so on, but also are the prefer material for intervention embolotherapy. While the fibrin glue can not only be local hemostasis, prevent conglutination and seepage, but also mainly be slow-release trager, bone material frame. However, different hemostasis materials have different hemostasis mechanisms and effects, so only to sufficiently comprehend the characteristic of different hemostasis materials can use them more reasonable and available.
 

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