Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (21): 3907-3910.doi: 10.3969/j.issn.1673-8225.2012.21.025

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Bone morphogenetic protein-2 expression in the surrounding tissues of calcium phosphate coating magnesium alloys

Sun Wei1, Zhang Guang-dao1, Tan Li-li2, Yang Ke2, Hong Yan-song1, Ai Hong-jun1   

  1. 1Department of Prosthodontics, School of Stomatology, China Medical University, Shenyang  110002, Liaoning Province, China; 2Institute of Metals Research, Chinese Academy of Sciences, Shenyang  110016, Liaoning Province, China
  • Received:2012-01-15 Revised:2012-03-15 Online:2012-05-20 Published:2012-05-20
  • Contact: Ai Hong-jun, Professor, Doctoral supervisor, Department of Prosthodontics, School of Stomatology, China Medical University, Shenyang 110002, Liaoning Province, China aih0620@yahoo.com.cn
  • About author:Sun Wei☆, Doctor, Lecturer, Department of Prosthodontics, School of Stomatology, China Medical University, Shenyang 110002, Liaoning Province, China sunway_77@yahoo.com.cn
  • Supported by:

    the Natural Science Foundation of Liaoning Province, No. 20082079*; Education Department Foundation of Liaoning Province, No. L2010644*, 2009A767*, 2008822*; Science and Technology Program Foundation of Shenyang City, No. F10-149-9-42*

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Abstract:

BACKGROUND: The alloy composition adjustment can improve the corrosion resistance and mechanical properties of magnesium alloys.
OBJECTIVE: To investigate bone morphogenetic protein-2 (BMP-2) expression in the soft tissues around calcium phosphate coating magnesium alloys.
METHODS: Twenty-seven healthy adult male Japanese white rabbits were randomly divided into calcium phosphate coating group, untreated group and titanium alloy group. We implanted calcium phosphate coating and untreated AZ31B magnesium alloy screws into the rabbits’ mandible, and titanium alloy group served as the control. The animals were sacrificed after 1, 2 and 3 months, and BMP-2 mRNA expressions were measured by reverse transcription-PCR.  
RESULTS AND CONCLUSION: With time passed, the BMP-2 mRNA expression showed a gradual increase for calcium phosphate coating group and untreated group, and significant differences exited in the calcium phosphate coating group at different time points (P < 0.05). The BMP-2 mRNA expression of the untreated group was significantly higher than that of the coating group at 1 and 2 months after implantation (P < 0.05). Calcium phosphate coating can promote the mRNA expression of BMP-2, which is beneficial to the early osteogenesis and shows good biological activity.
 

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