Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (21): 3886-3890.doi: 10.3969/j.issn.1673-8225.2012.21.020

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In vitro hemolysis test of a maglev centrifugal ventricular assist device

Wu Guang-hui1, Lin Chang-yan1, Chen Chen2, Yang Peng2, Qu Wen-bo2, Yao Ling-fei2, Wang Jing1   

  1. 1Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing  100029, China; 2China Heart Biomedical Incorporation, Suzhou  215125, Jiangsu Province, China; 3Beijing Anzhen Hospital, Capital Medical University, Beijing  100029, China
  • Received:2011-12-07 Revised:2012-01-12 Online:2012-05-20 Published:2012-05-20
  • Contact: Lin Chang-Yan, Doctor, Professor, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China assosiate@sina.com
  • About author:Wu Guang-hui★, Master, Assistant researcher, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China assosiate@sina.com
  • Supported by:

    National High Technology Research and Development Program of China (863 Program), No. 2009AA045401*; the Natural Science Foundation of Beijing, No. 3112011*

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Abstract:

BACKGROUND: Ventricular assist devices are widely used in patients with heart failure. Although different blood pumps have been developed and used throughout the world, few blood pumps are used in China because of the high prices. Development of a less expensive pump for clinical use is urgently needed in China.
OBJECTIVE: To test the hemolytic characteristics of an implantable magnetic suspension centrifugal ventricular assist device       in vitro.
METHODS: The flow field of the blood pump was analyzed with the computational fluid dynamics. Blood pumps were connected in a mock circulatory loop, filled with fresh sheep blood, and the pump generated 5 L/min flow against a head pressure of 100 mm Hg (1 mm Hg=0.133 kPa). The in vitro hemolytic properties were evaluated by determining the level of plasma free hemoglobin at defined intervals.
RESULTS AND CONCLUSION: Based on the computational fluid dynamics, a stable blood flow line was shown inside the pump, the wall shear stress inside the pump was less than 68.5 Pa and the internal static pressure distribution was smooth without adverse area. The normalized index of hemolysis was (0.075±0.017) mg/L. The blood pump showed satisfactory hemolytic properties as compared with the other third generation pumps. No mechanical failure occurred during the experiments. Therefore, long-term in vivo circulation assist experiment of the new blood pump could be carried on to evaluate its hemodynamics and end-organ effect in the future.

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