Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (21): 3869-3872.doi: 10.3969/j.issn.1673-8225.2012.21.016

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Clinical application of bio-artificial duramater in repair of dural defects in traumatic brain injury patients 

Luo Wu-feng, Li Han-cheng, Chen Man-hua, Liu Jun-bo, Hong Ying-biao   

  1. Department of Neurosurgery, Jieyang People’s Hospital, Jieyang  522000, Guangdong Province, China
  • Received:2011-10-15 Revised:2012-01-26 Online:2012-05-20 Published:2012-05-20
  • About author:Luo Wu-feng, Attending physician, Department of Neurosurgery, Jieyang People’s Hospital, Jieyang 522000, Guangdong Province, China luowufeng@126.com

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Abstract:

BACKGROUND: The integrity of the dura mater is very important for the prognosis of patients with head injury.
OBJECTIVE: To observe and analyze the clinical data regarding the application of bio-artificial duramater in dural relaxing suture in patients with traumatic brain injury as well as to evaluate the use value.
METHODS: We retrospectively reviewed the curative effects of bio-artificial duramater in the repair of dural defects in 132 cases of traumatic brain injury as well as follow-up results.
RESULTS AND CONCLUSION: By the end of 1-year follow-up, 64 patients were included in result analysis. After operation, there were 22 cases of hydrocephalus, eight cases of subcutaneous effusion, four cases of extradural hematoma, two cases of cerebrospinal fluid incision leakage and one case of rhinorrhea. After repair, head CT revealed no abnormal reactions related to bio-artificial duramater. Forty-two patients had a good fusion of artificial duramater and normal dura mater, and no adhesion and inflammatory reactions after 3-6 months. These findings indicate that bio-artificial duramater can reduce complications, have a good fusion with the normal dura mater and protect the cerebral cortex.

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