Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (20): 3663-3666.doi: 10.3969/j.issn.1673-8225.2012.20.012

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Expression of atuocrine motility factor in keloid

Zhang Jun-bo, Ya Zu-meng   

  1. Department of Plastic and Aesthetic Surgery, Second Affiliated Hospital of Chongqing Medical University, Chongqing  400010, China
  • Received:2011-12-30 Revised:2012-03-04 Online:2012-05-13 Published:2012-05-13
  • Contact: Ya Zu-meng, Doctor, Professor, Department of Plastic and Aesthetic Surgery, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China yazumeng@163.com
  • About author:Zhang Jun-bo★, Studying for master’s degree, Department of Plastic and Aesthetic Surgery, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China zhangjunbo0924@163.com
  • Supported by:

    General Program of the National Natural Science Foundation of China, No. 81071596*

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Abstract:

BACKGROUND: Autocrine motility factor (AMF) exhibits an improved expression in tumor cells, and it can enhance cell growth, invasion and metastasis. But keloid has biological characteristics of malignant tumor.
OBJECTIVE: To know about the expression of AMF in keloid, hypertrophic scar and normal scar tissues.
METHODS: Each 20 cases of keloid, hypertrophic scar and normal scar were studied, and three kinds of scar tissues were selected. The distribution and relative expression of AMF in the three kinds of scar tissues were assessed by immunofluorescence. Protein and mRNA level of AMF in scar tissues were analyzed by western blot and real-time PCR methods.
RESULTS AND CONCLUSION: In tissue, protein and mRNA levels, normal scar and hypertrophic scar tissues showed low expression of AMF. In distribution and relative expression, there was no significant difference between the normal scar and hypertrophic scar tissues. However, the keloid tissues showed significantly higher expression of AMF than normal scar and hypertrophic scar tissues in the three levels (P < 0.01). These findings suggest that AMF is highly related to tumor biological characteristics of keloid.

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