Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (16): 2989-2996.doi: 10.3969/j.issn.1673-8225.2012.16.031

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Classification, surface modification and biocompatibility of artificial cornea materials 

Wang Yang1, Xing Chun-sheng2, Zhou Xing1, Wang Lei1, Han Hong-guang3   

  1. 1Department of Ophthalmology, Shenxiang No. 705 Hospital, Shenyang 110015, Liaoning Province, China;2Out-patient Department of Liaoning Military Region, Shenyang 110032, Liaoning Province, China;3Department of Cardiovascular Surgery, General Hospital of Shenyang Military Region,Shenyang  110016Liaoning Province, China
  • Received:2012-01-20 Revised:2012-03-30 Online:2012-04-15 Published:2012-04-15
  • Contact: Han Hong-guang, Doctor, Associate chief physician, Master’s supervisor, Department of Cardiovascular Surgery, General Hospital of Shenyang Military Region, Shenyang 110016, Liaoning province, China hanxiyao@163.com
  • About author:Wang Yang★, Master, Attending physician, Department of Ophthalmology, Shenxiang No. 705 Hospital, Shenyang 110015, Liaoning Province, China xuemianyang@sina.com

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Abstract:

BACKGROUND: Corneal disease and cataracts are the main reason that causes blindness, which can be cured by corneal transplantation. As the emergence of artificial cornea, make the corneal transplantation get rid of the problem in lacking of donor and transplant success rate, bring new hope for patients with corneal blindness.
OBJECTIVE: Using CNKI database literature search and the depth of analysis capabilities, explore the multi-level analysis for the study of artificial cornea and artificial cornea materials classification and design of the literature data trends.
DESIGN: Bibliometric data analysis.
DATA RETRIEVAL: A search of related literature of artificial cornea materials research was performed in CNKI database using the key words of “Artificial cornea”, “Biomaterials”, “Biocompatibility”, “Hydrogel”, “Hydroxyapatite(HA)”, during 2002/1 to 2011/12. Using own database analysis capabilities and Excel charting functions to retrieve literature analysis, through the form of text and charts analysis the data , to describe its distribution characteristics.
SELECTION CRITERIA: ①Basic research papers related to the artificial cornea materials.②Papers related to the clinical application of artificial cornea materials.③The research papers related to the classification of artificial cornea materials. ④Research papers related to the design of artificial cornea materials. Exclusion criteria: ①Literature has nothing to do with the purpose of this review. ②Duplication of research literature. ③Journal's own information. ④Unpublished papers. ⑤The article need telephone follow up to analyze and manual searches. ⑥Yearbook.
MAIN OUTCOME MEASUREMENTS: In CNKI database, using academic journal articles published year, literature number, subject category, research institutions, source journals, literature citations, literature download frequency, associated literature, distribution of the author, distribution of the Funds and major keywords to analysis.
RESULTS: The literature associated with academic journals in CNKI during 2002-2011, retrieved a total of 48 artificial cornea materials research literature. The number of papers was gradually increasing. Published the most in 2005, a total of 9. Journal of Clinical Rehabilitative Tissue engineering Research published literatures is 9, accounting for 18.8% of all literature. The artificial cornea materials science research funded mainly by the National Natural Science Foundation of China. The artificial cornea materials research mainly based on hydrogel and hydroxyapatite, to highlight the material surface modification and biocompatibility studies.
CONCLUSION: Through the bibliometric data analysis based on CNKI database of academic journal literature of the artificial cornea materials, to provide valuable reference for Chinese medical worker in artificial cornea material science basic research and clinical practice, to further define the thinking of scientific research.

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