Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (15): 2762-2766.doi: 10.3969/j.issn.1673-8225.2012.15.022

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Low-frequency pulsed ultrasound versus hormone blockade for the treatment of tendinopathy in rats

Xu Xi-dong, Liu Wei, Liu Miao, Si Hai-bo, Chen Shi-rong   

  1. Department of Orthopedics, Second Affiliated Hospital of Chongqing Medical University, Chongqing  400010, China
  • Received:2011-09-30 Revised:2011-10-19 Online:2012-04-08 Published:2012-04-08
  • About author:Xu Xi-dong★, Studying for master’s degree, Department of Orthopedics, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China ccllxxxx@126.com

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Abstract:

BACKGROUND: Low-frequency pulsed ultrasound is widely used in the treatment of chronic soft tissue injuries.
OBJECTIVE: To establish a rat model of tendinopathy and to observe the therapeutic effects of low-frequency pulsed ultrasound versus hormone blockade.
METHODS: Totally 60 Sprague-Dawley rats were randomly divided into two groups: black control group (10 rats) and experimental group (50 rats) which received electric stimulus for 8 weeks to construct the rat models of tendinopathy. After modeling successfully, low frequency ultrasound, corticosteroid local blocking, and 4 week simple rest were performed. The number and height of jumping were recorded. Hematoxylin-eosin staining, sirius-red staining and Tunnel staining were used to observe the pathological changes.
RESULTS AND CONCLUSION: Jumping ability of the rats firstly increased then decreased during modeling. After modeling successfully, Achilles tendon tide line increased, Ⅰ/Ⅲ type collagen ratio inversed and apoptosis increased. In the low frequency ultrasound group, the Achilles tendon collagen ratio was obviously recovered and apoptosis was decreased, but which in the hormone blockade and simple rest groups had no obvious changes. It is suggested that low-frequency pulsed ultrasound can be used for the tendinopathy treatment, and has a protective effect on Achilles tendon.
 

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