Abstract:

BACKGROUND: Studies have found that the cytokine participates in the formation of osteoarthritis by influencing balance between catabolism and anabolism of articular cartilage matrix. Interleukin 1β (IL-1β) and tissue inhibitors of matrix metalloproteinase 1 (TIMP-1) play an important role.
OBJECTIVE: To investigate the effect of endogenous cytokines, IL-1β and TIMP-1, on cataplasia of articular cartilage of osteoarthritis.
METHODS: Thirty-seven patients with knee osteoarthritis were studied who were treated in the Fifth Affiliated Hospital of Harbin Medical University during 2006-06/2009-09. Extraction of synovial fluid and separation of smooth and shining synovial membrane tissues were performed during microscopic examination in patients. Ten specimens of normal synovial fluid and smooth and shining synovial membrane tissue were used as control.
RESULTS AND CONCLUSION: In the osteoarthritis patients, the levels of IL-1β and TIMP-1 in synovial fluid and synovial membrane tissue were all significantly higher than those in the normal synovial fluid, the synovial fluid concentration of IL-1β and TIMP-1 were positively related to the severity of osteoarthritis. These findings demonstrate that the level of IL-1β and TIMP-1 are related with osteoarthritis and cartilage degradation.