Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (14): 2625-2628.doi: 10.3969/j.issn.1673-8225.2012.14.031

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Autologous bone marrow stem cells transplantation in the treatment of lower limb ischemia

Yu Gui-ping, Wang Zhong   

  1. Department of Cardiothoracic Surgery, the Affiliated Jiangyin Hospital of  Medical College of Southeast University, Jiangyin  214400, Jiangsu Province, China
  • Received:2011-07-23 Revised:2011-08-22 Online:2012-04-01 Published:2012-04-01
  • Contact: author: Yu Gui-ping, ngyin Hospital of MeStudying for doctorate, Department of Cardiothoracic Surgery, the Affiliated Jiadical College of Southeast University, Jiangyin 214400, Jiangsu Province, China xiaoyuer97103@163.com
  • About author:Yu Gui-ping☆, Studying for doctorate, Department of Cardiothoracic Surgery, the Affiliated Jiangyin Hospital of Medical College of Southeast University, Jiangyin 214400, Jiangsu Province, China

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Abstract:

BACKGROUND: Bone marrow stem cells can promote the ischemic limb angiogenesis, the formation of new collateral vessels, and improve local blood supply through a variety of mechanisms.
OBJECTIVE: To review the effect of bone marrow stem cells transplantation in the treatment of lower limb ischemia.
METHODS: PubMed and CNKI were retrieved using computer to search relevant articles published from December 2001 to December 2011, and the keywords were “bone marrow stem cells, lower extremists ischemia”.
RESULTS AND CONCLUSION: Bone marrow stem cells can migrate to the site of lower limb ischemia, and participate in tissue regeneration, formation and secretion of many vasoactive growth factors to promote angiogenesis, promote cell proliferation and differentiation, which are conducive to tissue and cell regeneration. However, there are still many questions to be solved, such as preservation of seed cells, regulatory mechanism of cell differentiation and proliferation in vitro, biomechanical properties of skeletal muscle cells, cellular and molecular biological characteristics of cells in repaired tissues.

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