Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (11): 1906-1909.doi: 10.3969/j.issn.1673-8225.2012.11.002

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Effect of adiponectin on bone regeneration following rapid mandibular distraction osteogenesis in rabbits 

Shui Xue-ping1, Jiang Xiao-wen2, Ye Bin1, Hu Jing1   

  1. 1Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu  610041, Sichuan Province, China; 2Department of Stomatology, the First People’s Hospital of Chenzhou, Chenzhou  423000, Hunan Province, China
  • Received:2011-08-24 Revised:2011-10-19 Online:2012-03-11 Published:2012-03-11
  • Contact: author: Hu Jing, Professor, Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China drhu@vip.sohu.com
  • About author:Shui Xue-ping☆, Studying for doctorate, Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China 0475022155@ stu.scu.edu.cn

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Abstract:

BACKGROUND: Adiponectin participates in bone metabolism and angiogenesis, which is beneficial for bone growing. However, the effect of adiponectin on bone regeneration following distraction osteogenesis is not clear.
OBJECTIVE: To investigate the effects of intermittent local administration of adiponectin on bone regeneration following establishment of rapid mandibular distraction models in rabbits.
METHODS: Sixteen New Zealand white rabbits were randomly divided into experimental group and control group. Rapid unilateral mandibular distraction osteogenesis models were established with 2 mm/d distraction rate. At the 1, 3 and 5 days of the distraction, 200 μL of phosphate buffer solution or 200 μL of phosphate buffer solution containing 2 μg recombinant human adiponectin was intermittently injected into the distraction gap of the control and experimental groups, respectively.
RESULTS AND CONCLUSION: Bone regeneration was found in the distracted callus from both groups. Histological observation and micro-CT examinations confirmed that the new bone formation and mineralization of the distraction callus in experimental group was significantly greater than that of the control group. Intermittent administration of adiponectin can markedly promote the bone regeneration in rabbit rapid mandibular osteodistraction.

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