Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (11): 1910-1914.doi: 10.3969/j.issn.1673-8225.2012.11.003

Previous Articles     Next Articles

Effects of recombinant human bone morphogenetic protein combined with basic fibroblast growth factor on the repair of articular cartilage defects

Zhu Guo-hua1, Cai Jian-ping1, Guo Cui-ling1, Liao Jia-xin1, Liu Yong1, Luo Hong-tao1, Xu Guo-hua2, Hu Hong-tao2   

  1. 1Institute of Orthopedics, Wuxi Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Wuxi  214001, Jiangsu Province, China;    2Institute of Orthopedics, Changzheng Hospital, the Second Military Medical University of Chinese PLA, Shanghai  200003, China
  • Received:2011-07-09 Revised:2011-07-20 Online:2012-03-11 Published:2012-03-11
  • About author:Zhu Guo-hua★, Master, Associate chief physician, Institute of Orthopedics, Wuxi Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Wuxi 214001, Jiangsu Province, China zhuguohuazhu@163.com
  • Supported by:

    Program of Science and Technology of Wuxi Technology Bureau in Jiangsu Province, No. CSZ00857*

PDF

390

Cited

2

Abstract:

BACKGROUND: The synergy of various cell growth factors attracts more and more attention in the course of cartilage metabolism. However, there are few reports of repairing cartilage defects with combined cell growth factors, and the effect remains unknown at present.
OBJECTIVE: To study the repairing effect of recombinant human bone morphogenetic protein (rhBMP) combined with basic fibroblast growth factor (bFGF) on articular cartilage defects.
METHODS: After the model of articular cartilage defects was made, 24 Japan big-eared white rabbits were randomly divided into four groups for intervention: rhBMP combined with bFGF (group A), single rhBMP (group B), single bFGF (group C), the fourth group was without injection and just filled with gelatin sponge (group D).
RESULTS AND CONCLUSION: In general observation, articular cartilage defects were basically repaired but slightly uneven in group A, and there were no defects entirely repaired in groups B and C. In group D, articular cartilage defects were not repaired. The number of cartilage cells in group A was more than that in groups B, C and D (P < 0.05). The positive number of type Ⅱ collagens by immunohistochemical staining in group A was higher than that in the other groups. It indicated that rhBMP combined with bFGF could accelerate the formation of new articular cartilage, and had better effect than rhBMP or bFGF alone. 

CLC Number: